Catfish farming is the largest aquaculture industry in the United States and an important economic driver in several southeastern states. Edwardsiella piscicida is a Gram‐negative pathogen associated with significant losses in catfish aquaculture. Several Gram‐negative bacteria use the BasS/BasR two‐component system (TCS) to adapt to environmental changes and the host immune system. Currently, the role of BasS/BasR system in E...

Edwardsiella piscicida is a Gram‐negative facultative intracellular bacterium causing edwardsiellosis in catfish, the largest aquaculture industry in the United States. A safe and effective vaccine is an urgent need to avoid economic losses associated with E. piscicida outbreaks. PhoP/PhoQ is a two‐component signal transduction system (TCS) that plays an important role in bacterial pathogenesis through sense and response to en...