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Submarine cables are critical components for power transmission in offshore wind farms, making their condition monitoring paramount for ensuring operational reliability. Addressing unclear strain transfer and underdeveloped Brillouin optical time-domain reflectometry (BOTDR) sensing models for three-core fiber-optic composite submarine cables, this study investigated a 66 kV cable and clarified a BOTDR monitoring principle bas...
Pharmacokinetic Modeling of the Effect of Tariquidar on Ondansetron Disposition into the Central Nervous SystemNARA Subscribed
Purpose Serotonin (5-HT 3 ) receptor antagonists are promising agents for treatment of neuropathic pain. However, insufficient drug exposure at the central nervous system (CNS) might result in lack of efficacy. The goal of this study was to evaluate the impact of administration of a Pgp inhibitor (tariquidar) on ondansetron exposure in the brain, spinal cord, and cerebrospinal fluid in a wild-type rat model. Methods Ondansetro...
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