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Springer Nature1
Journal
Molecular Neurobiology1
Publication Year
20221
Marc Aurel Busche results 1 · Newest (Page 1/1, per page 25)
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The β-Secretase Substrate Seizure 6–Like Protein (SEZ6L) Controls Motor Functions in MiceNARA Subscribed
Molecular Neurobiology · 2022 · Vol. 59 · Issue 2 · Springer
Emma Ong-Pålsson; Jasenka Rudan Njavro; Yvette Wilson; Martina Pigoni; Andree Schmidt; Stephan A. Müller; Michael Meyer; Jana Hartmann; Marc Aurel Busche; Jenny M. Gunnersen; Kathryn M. Munro; Stefan F. Lichtenthaler
The membrane protein seizure 6–like (SEZ6L) is a neuronal substrate of the Alzheimer’s disease protease BACE1, and little is known about its physiological function in the nervous system. Here, we show that SEZ6L constitutive knockout mice display motor phenotypes in adulthood, including changes in gait and decreased motor coordination. Additionally, SEZ6L knockout mice displayed increased anxiety-like behaviour, although spati...
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