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Computing optimal drug dosing regarding efficacy and safety: the enhanced OptiDose method in NONMEMNARA Subscribed
Recently, an optimal dosing algorithm (OptiDose) was developed to compute the optimal drug doses for any pharmacometrics model for a given dosing scenario. In the present work, we enhance the OptiDose concept to compute optimal drug dosing with respect to both efficacy and safety targets. Usually, these are not of equal importance, but one is a top priority, that needs to be satisfied, whereas the other is a secondary target a...
Berechnung von Temperaturfahnen im Grundwasser mit analytischen und numerischen ModellenNARA Subscribed
Zusammenfassung Mit zunehmender Anzahl an Grundwasserwärmepumpenanlagen steigt auch das Potenzial an Nutzungsüberlagerungen. Im Rahmen des wasserrechtlichen Genehmigungsverfahrens ist es daher erforderlich, u. a. die von einer Anlage ausgehenden Temperaturfahnen im Grundwasser zu berechnen. In Baden-Württemberg wurde als Erweiterung des für Anlagen ≤ 45.000 kWh/a gültigen Leitfadens des Umweltministeriums Baden-Württemberg das...
EPMA-World Congress 2015NARA Subscribed
Enigmatic SebacinalesNARA Subscribed
Tracking of human cells in miceNARA Subscribed
Whole genome analysis of the marine Bacteroidetes ‘ Gramella forsetii ’ reveals adaptations to degradation of polymeric organic matterNARA Subscribed
Summary Members of the Bacteroidetes , formerly known as the Cytophaga‐Flavobacteria‐Bacteroides (CFB) phylum, are among the major taxa of marine heterotrophic bacterioplankton frequently found on macroscopic organic matter particles (marine snow). In addition, they have been shown to also represent a significant part of free‐living microbial assemblages in nutrient‐rich microenvironments. Their abundance and distribution patt...
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