Candida parapsilosis sensu stricto has emerged as a major cause of healthcare-associated candidemia, with increasing reports of fluconazole resistance worldwide. This resistance is most commonly associated with amino acid substitutions in Erg11p, particularly Y132F; however, regional variation in resistance mechanisms and clonal dissemination remains not fully understood. This study investigated the molecular epidemiology and...

The objective of this study was to evaluate the effects of immunocastration and ractopamine hydrochloride (RAC) supplementation on growth performance and carcass traits of male pigs slaughtered 21 days after the second immunization. Sixty-four pigs (Landrace × Large White, initial body weight 103.05 ± 0.67 kg) were individually tagged and randomly assigned to a 2 × 2 factorial arrangement in a completely randomized design, con...

Organotellurium (OTe) compounds have pharmacological properties, including leishmanicidal, antimalarial, and antifungal activities. Herein, we assessed cytotoxicity effects of OTe RF07 in a panel of tumor cell lines, as well as its oxidative, toxicity, and hemolytic actions. The toxicity was evaluated on Allium cepa and Artemia salina larvae. Cell viability was also assessed by resazurin in murine cells (Sarcoma 180), human ce...

The search for sustainable agricultural inputs has increased the interest in biostimulants based on macroalgae. An aqueous extract of Kappaphycus alvarezii , a red seaweed rich in bioactive compounds, has emerged as a promising biostimulant for various crops, in Brazil, but its effects on barley ( Hordeum vulgare L.) remain underexplored. This study investigated the influence of foliar application of different concentrations,...

Respiratory diseases remain a major public health challenge in tropical coastal cities, where persistent heat-humidity interactions and climate variability shape population vulnerability. This study quantified associations between atmospheric conditions and respiratory hospitalizations in Maceió, Brazil, using a 20-years time series (2000–2019). Weekly hospitalization rates stratified by age (children 0–4 years, adults 5–59 ye...

Background Streptococcus pyogenes (GAS) causes diseases ranging from mild pharyngitis to severe invasive infections. The emm 1 type is the most prevalent worldwide, and a highly transmissible variant, M1 UK , characterized by increased speA expression, has recently emerged and spread globally. Objective To characterize the genomic diversity of invasive GAS isolates collected from severe cases and epidemiologically important ou...

Background and aims Pre-sprouted sugarcane seedlings are increasingly used to ensure uniform crop establishment; however, their performance is highly constrained by water deficit under climate change scenarios. This research evaluated whether a consortium of Bacillus licheniformis (FMCH001) and Bacillus subtilis (FMCH002) could mitigate drought stress by improving root development, soil microbial activity, and plant nutritiona...

The supply of metabolizable nutrients to suckling beef calves on pasture can improve their performance, increasing weaning weight and productivity in cow–calf systems. The objective was to evaluate the effects of dried distillers grains (DDG) inclusion on intake, digestibility, metabolism, and performance of suckling beef calves grazing tropical pastures. Forty-eight Nellore calves, 120 ± 35 days of age and 135 ± 23.4 kg of bo...

Multiform glioblastoma (GBM) is the most aggressive primary brain tumor, associated with high heterogeneity, treatment resistance, and poor survival. Temozolomide (TMZ), although the main chemotherapeutic agent used, shows limited efficacy due to low solubility, chemical instability, and acquired resistance. In this context, nanostructured systems can enhance their antitumor efficacy. This study aimed to develop and characteri...

Understanding Neotropical megadiversity remains challenging due to fundamental taxonomic issues, including identifying and describing cryptic species and their distribution, and the limited knowledge of key factors driving biological diversification. Such challenges are especially prominent in diverse clades with high levels of cryptic species, such as many Neotropical frogs. Herein, we conduct a mitochondrial phylogenetic stu...

Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...