Marcus Fischer results 13
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Purpose Despite persistent bleeding and thrombotic adverse events in patients supported with blood pumps, standardized preclinical assessment of hemocompatibility remains largely restricted to hemolysis testing. To advance the field, robust and comparable in vitro platelet function testing within mock-loop mechanical circulatory support (MCS) studies is needed. This review systematically summarizes current methodologies for pl...
Background Mesenchymal stromal/stem cells (MSCs) have been suggested for salivary gland (SG) restoration following radio-induced salivary gland damage. This study aimed to determine the safety and effectiveness of MSC therapy on radio-induced SG damage and hypofunction in preclinical in vivo studies. Methods PubMed and EMBASE were systematically searched for preclinical in vivo interventional studies evaluating efficacy and sa...
Differential regulation of extracellular matrix proteins in three recurrent liver metastases of a single patient with colorectal cancerNARA Subscribed
Colorectal cancer (CRC) patients suffer from the second highest mortality among all cancer entities. In half of all CRC patients, colorectal cancer liver metastases (CRLM) can be observed. Metastatic colorectal cancer is associated with poor overall survival and limited treatment options. Even after successful surgical resection of the primary tumor, metachronous liver metastases occur in one out of eight cases. The only avail...
Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyon...
NEOTROPICAL XENARTHRANS: a data set of occurrence of xenarthran species in the NeotropicsNARA Subscribed
Xenarthrans—anteaters, sloths, and armadillos—have essential functions for ecosystem maintenance, such as insect control and nutrient cycling, playing key roles as ecosystem engineers. Because of habitat loss and fragmentation, hunting pressure, and conflicts with domestic dogs, these species have been threatened locally, regionally, or even across their full distribution ranges. The Neotropics harbor 21 species of armadillos,...
The genomic basis of adaptation to calcareous and siliceous soils in Arabidopsis lyrataNARA Subscribed
Edaphic conditions are important determinants of plant fitness. While much has been learnt in recent years about plant adaptation to heavy metal contaminated soils, the genomic basis underlying adaptation to calcareous and siliceous substrates remains largely unknown. We performed a reciprocal germination experiment and whole‐genome resequencing in natural calcareous and siliceous populations of diploid Arabidopsis lyrata to t...
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