Oxidative stress is a common event in a variety of chronic diseases and its detection is confined to equipped laboratories with dedicated instruments and with personnel with high specialization. Electrochemical sensors have been demonstrated to be effective, easy-to-use, and reliable tools for quantifying extracellular hydrogen peroxide (H₂O₂) in airway epithelial preclinical models. Economic analyses of biomedical studies are...

Neuroblastoma (NB) is a highly vascularized pediatric tumor arising from undifferentiated neural crest cells early in life, exhibiting both traditional endothelial-cell-driven vasculature and an intriguing alternative vasculature. The alternative vasculature can arise from cancer cells undergoing transdifferentiation into tumor-derived endothelial cells (TEC), a trait associated with drug resistance and tumor relapse. The lack...

Bone pain typically occurs immediately following skeletal damage with mechanical distortion or rupture of nociceptive fibres. The pain mechanism is also associated with chronic pain conditions where the healing process is impaired. Any load impacting on the area of the fractured bone will stimulate the nociceptive response, necessitating rapid clinical intervention to relieve pain associated with the bone damage and appropriat...