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A versatile plasmid platform for auxotrophic complementation in attenuated Mycobacterium bovis BCGNARA Subscribed
Background Mycobacterium bovis BCG is widely used as a vaccine vector due to its safety, genetic stability, and immunomodulatory properties. However, current expression systems for BCG transformation rely on antibiotic resistance genes, raising biosafety concerns. Therefore, alternative strategies—such as the use of auxotrophic strains—are highly desirable. Our group previously employed BioBrick™ technology to construct the pU...
Combined family-based association and linkage analyses in families affected by attention-deficit hyperactivity disorderNARA Subscribed
Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent and heritable of neurodevelopmental disorders. To characterize the genetic variants contributing to this heritability, we studied families with members affected by ADHD. Genome-wide array data were obtained on two cohorts: NHGRI Family Cohort (359 nuclear families,1538 individuals) and NCR Family Cohort (25 multigenerational and 132 nuclear families,...
Assessment of cytotoxicity and genomic instability induced by coal-derived nanoparticles in V79 and HaCaT CellsNARA Subscribed
Coal is a major global energy resource, but its extraction raises significant environmental and health concerns. Mining activities release large amounts of particulate matter, including nanoparticles (NPs), into the environment. These NPs are hazardous due to their content of polycyclic aromatic hydrocarbons (PAHs), metals, oxides, and other compounds capable of disrupting cellular and molecular processes. This study evaluated...
Lichen-derived atranorin effects on cultivable gut-associated bacteria in Constrictotermes cyphergasterNARA Subscribed
Chemical defenses produced by lichens represent a yet underexplored force shaping trophic interactions beyond direct consumer deterrence. In termites, dietary intake of such compounds may extend their effects to gut-associated microbial consortia, with consequences for host physiology and colony performance. However, the extent to which lichen-derived metabolites influence microorganisms in insect hosts remains poorly understo...
Oncogenetics training in Brazilian medical genetics residency programs: current landscape and challengesNARA Subscribed
Oncogenetics focuses on identifying and managing hereditary cancer predisposition, enabling risk-reducing interventions and targeted therapies. This descriptive study evaluated the landscape of oncogenetics training within Medical Genetics Residency Programs in Brazil. Data were collected through online questionnaires and interviews with program supervisors. We assessed rotation availability, timing and duration, clinical and...
A dataset of plant communities invaded by Acacia sp. pl. and Robinia pseudoacacia in ItalyNARA Subscribed
The full extent of the ecological threat posed by non-native invasive leguminous N-fixing trees to Italian ecosystems has not been thoroughly documented at the national level. This study, conducted by the Working Group on Alien Species of the Italian Botanical Society, aims to develop a comprehensive dataset that provides information on invaded and non-invaded areas, supporting multi-scale ecological analyses on the impact of...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Purpose Systematic collection and analysis of antimicrobial resistance data from key bacterial pathogens is essential to contribute to control antimicrobial resistance (AMR). The aim of this work was to survey the drug resistance on clinically relevant organisms stratified according to age, gender, clinical specimens and facilities. Methods Microbiological data were collected from 55 centers across 24 states in Mexico between...
Ti solubility in biotite at low pressure in metapelitic systems: the Torres del Paine caseNARA Subscribed
The Torres del Paine Intrusive Complex (TPIC) is a shallowly emplaced pluton surrounded by a well-defined contact aureole, providing an ideal setting to test Ti-in-biotite thermometry. We compare existing Ti-in-biotite thermometers with phase petrology constraints and found that they systematically overestimate peak metamorphic temperatures. This discrepancy arises from a significant increase in Ti solubility at low pressures...
Non-native insects are often inconspicuous organisms that can negatively impact the economy, biodiversity, and public health. Field crickets (Orthoptera: Gryllidae: Gryllinae) have historically been used as a food source for livestock, pets, and humans—a practice that likely facilitated the spread of certain species into urban centers and non-native habitats. Although rarely cited as invasive, species like Gryllodes sigillatus...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Mind the Gaps: Shortfalls in Studies of the Intraspecific Genetic Diversity of Plants Across the Gran ChacoNARA Subscribed
Intraspecific genetic diversity (IGD) is a fundamental component of biodiversity, essential for understanding the evolutionary histories and demographic processes of species, and is key to effective conservation planning. However, ecologically important regions such as the Gran Chaco, South America's second‐largest forested biome, remain largely underexplored. Encompassing diverse vegetation across climatic and altitudinal gra...