Background Neuroinflammation involves the activation of glial cells, particularly astrocytes, and microglia, in response to pathological stimuli. Astrocyte activation is characterized by increased pro-inflammatory cytokines and oxidative stress. Given their role in neuroinflammation, targeting astrocytic mechanisms presents potential therapeutic opportunities. Ellagic acid (EA), a phenolic compound, exhibits antioxidant, anti-...

Background Urothelial Bladder Cancer (UBC) remains a significant clinical challenge due to its high morbidity, substantial economic burden, and high recurrence rates. E-cadherin, an important regulator of cell-cell adhesion encoded by the CDH1 gene, is frequently downregulated during malignant progression, serving as a hallmark of invasiveness. This study explored the prognostic significance of CDH1 genetic variants (rs16260 C...

Background The Passiflora genus presents a representative variability of passion fruit species with food, pharmacological and ornamental potential. To understand this genetic variability, it is essential that genetic resources are well characterized for future use in breeding and conservation programs. The aim of this study was to investigate for the first time the diversity genetic and structure population of 88 Passiflora ge...

Background Dysregulation of the innate immune response to SARS-CoV-2 has been linked to poor outcomes in COVID-19. Neutrophils are key players in this response, displaying distinct functional profiles associated with disease severity. This study investigates how neutrophil phenotypes, and their mediators are modulated in severe COVID-19 following vaccination. Methods and Results We conducted an observational case-control study...

Background This study explored the effect of blackberry fruit extract (BFE) and metformin (Met) on biochemical markers, redox parameters, and the downstream insulin signaling pathway in a high-fat diet (HFD) + streptozotocin (STZ) induced Type 2 Diabetic Rat model. Methods The identification and quantification of cyanidin-3-glucoside by HPLC in the BFE revealed a concentration of 28.33 ± 0.05 mg/g of dry extract. For in vivo s...

Bacterial diseases associated with the Mollicutes class can lead to decreased milk production and reproductive disorders in cattle, causing significant economic losses and compromising animal welfare. This study aimed to investigate the presence of Mollicutes and Ureaplasma diversum in the reproductive tract of dairy cows and determine the associated risk factors, as well as identify circulating strains of Ureaplasma in herds....

Understanding the genetic regulation underlying host–microbiota interactions is key to elucidating how microbial communities influence host metabolism, immunity, and physiology. In this context, the main objective of this study was to integrate genomic, transcriptomic, and microbial data to identify shared regulatory variants, highlight key microbial taxa, and prioritize biological pathways related to lipid metabolism, immune...

Maize is a crop that plays a fundamental role in global food security, particularly in tropical and subtropical regions. However, drought stress remains one of the major constraints that limit maize production worldwide. Maize sensitivity to water deficit is especially critical during the flowering stage, often resulting in substantial yield losses. This study aimed to investigate a sustainable strategy to mitigate drought str...