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Springer Nature1
Journal
Drug Delivery and Translational Research1
Publication Year
20261
Maria E. Ferrini results 1 · Newest (Page 1/1, per page 25)
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Encapsulation of the lipidated TLR7/8 agonist INI-4001 into ionic liposomes impacts H7 influenza antigen-specific immune responsesNARA Subscribed
Drug Delivery and Translational Research · 2026 · Vol. 16 · Issue 2 · Springer
Fatemeh Mehradnia; Hardik Amin; Maria E. Ferrini; Haley Partlow; Timothy Borgogna; Soma Shekar Dachavaram; Kendal T. Ryter; Hélène G. Bazin; Jay T. Evans; David J. Burkhart; Blair DeBuysscher; Walid M. Abdelwahab
Toll-like receptors (TLRs) are the best characterized family of Pattern Recognition Receptor-targeting adjuvants. Activation of TLR7/8 in particular, enhances antigen presentation by dendritic cells and macrophages, boosting Th1-mediated adaptive immune responses. However, poor pharmacokinetics and systemic toxicity of some TLR7/8 ligands hinder their clinical translation. Lipidation and incorporation of TLR7/8 ligands into li...
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