Purpose To determine the best kinetic model to be applied on dynamic brain [ 18 F]FDG PET images by characterizing the regional brain glucose metabolism of normal Göttingen minipigs. Methods Nine Göttingen minipigs were scanned with a clinical PET/CT tomograph, starting from the injection of an intravenous bolus of [ 18 F]FDG, for about 25 min. Dynamic images were reconstructed and nine brain regions of interest (ROI), plus a...

Accurate statistical model of PET measurements is a prerequisite for a correct image reconstruction when using statistical image reconstruction algorithms, or when pre-filtering operations must be performed. Although radioactive decay follows a Poisson distribution, deviation from Poisson statistics occurs on projection data prior to reconstruction due to physical effects, measurement errors, correction of scatter and random c...