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Brain Structure and Function · 2024 · Vol. 229 · Issue 5 · Springer
The expression of Neuritin-1 ( NRN1 ), a neurotrophic factor crucial for neurodevelopment and synaptic plasticity, is enhanced by the Brain Derived Neurotrophic Factor ( BDNF ). Although the receptor of NRN1 remains unclear, it is suggested that NRN1’s activation of the insulin receptor (IR) pathway promotes the transcription of the calcium voltage-gated channel subunit alpha1 C ( CACNA1C ). These three genes have been indepen...