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Physicians’ gender and specialty in relation to adverse drug reaction reporting in SwedenNARA Subscribed
Purpose To evaluate the possible influence of gender and specialty on adverse drug reaction (ADR) reporting among physicians before and after the COVID-19 pandemic. Methods This retrospective nationwide register study analysed all ADR reports submitted by physicians to the Swedish Medical Products Agency during 2017 and 2023 ( n = 4079 and 3740, respectively). The reporting rates were calculated and stratified by gender and sp...
Assessing local adaptation and divergence at early life stages within Eastern Baltic cod ( Gadus morhua )NARA Subscribed
Many commercially exploited fish stocks have declined over the last few decades. It is therefore essential to identify natural populations and understand local adaptation for sustainable management. Salinity is a key environmental factor shaping local adaptation, and adaptive trait divergence often occurs at the egg and larval stages. The strong salinity gradient in the brackish Baltic Sea has driven rapid adaptation in multip...
Blood-based biomarkers of Alzheimer’s disease and olfactory decline over 15 years in older adultsNARA Subscribed
Olfactory impairment is common in older age and is a known early feature of several dementia diseases. Blood-based biomarkers of Alzheimer’s disease (AD) now offer a scalable method for detecting pathophysiological mechanisms related to olfactory decline in the general population. However, few studies have examined how these biomarkers relate to long-term olfactory trajectories. Most existing work has been limited to cross-sec...
Nationwide multicentre study of Nanopore long-read sequencing for 16S rRNA-species identificationNARA Subscribed
Purpose Recent improvements in Nanopore sequencing chemistry has made it a promising platform for long-read 16S rRNA sequencing. This study evaluated its clinical utility in a nationwide collaboration coordinated by Genomic Medicine Sweden. Methods Thirteen mock samples comprised of various bacterial strains and an External Quality Assessment (EQA) panel from QCMD (Quality Control for Molecular Diagnostics) were analysed by 20...
Olfactory dysfunction increases progression to dementia in cognitively impaired older adults: a 12-year population-based studyNARA Subscribed
Olfactory deficits are hypothesized to precede cognitive decline and be independently associated with future dementia. Conversely, the concurrency of cognitive and olfactory impairments is expected to represent an advanced stage, associated with shorter time to diagnosis. Limited research has examined the association of isolated and concurrent cognitive and olfactory impairments with incident dementia. We aimed to estimate the...
Subclinical cognitive deficits are associated with reduced cerebrovascular response to visual stimulation in mid-sixties menNARA Subscribed
Reduced cerebrovascular response to neuronal activation is observed in patients with neurodegenerative disease. In the present study, we examined the correlation between reduced cerebrovascular response to visual activation (ΔCBF Vis.Act ) and subclinical cognitive deficits in a human population of mid-sixties individuals without neurodegenerative disease. Such a correlation would suggest that impaired cerebrovascular function...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Carriage of ESBL-producing Enterobacterales in wastewater treatment plant workers and surrounding residents — the AWARE StudyNARA Subscribed
To investigate whether wastewater treatment plant (WWTP) workers and residents living in close proximity to a WWTP have elevated carriage rates of ESBL-producing Enterobacterales, as compared to the general population. From 2018 to 2020, we carried out a cross-sectional study in Germany, the Netherlands, and Romania among WWTP workers (N = 344), nearby residents (living ≤ 300 m away from WWTPs; N = 431) and distant residents (...
Cold-water coral (CWC) habitats dwell on continental shelves, slopes, seamounts, and ridge systems around the world’s oceans from 50 to 4000 m depth, providing heterogeneous habitats which support a myriad of associated fauna. These highly diverse ecosystems are threatened by human stressors such as fishing activities, gas and oil exploitation, and climate change. Since their life-history traits such as long lifespan and slow...