The COVID-19 pandemic, caused by SARS-CoV-2, has resulted in millions of infections and deaths. Studies describing the pathophysiology and characterizing the outcome of the disease in specific populations, including those living with HIV, are necessary. There is no consensus on whether the disease worsens in immunosuppressed patients, which is considered a risk factor, or if immunosuppression might confer protection against cy...

Multiform glioblastoma (GBM) is the most aggressive primary brain tumor, associated with high heterogeneity, treatment resistance, and poor survival. Temozolomide (TMZ), although the main chemotherapeutic agent used, shows limited efficacy due to low solubility, chemical instability, and acquired resistance. In this context, nanostructured systems can enhance their antitumor efficacy. This study aimed to develop and characteri...

Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...

Western dietary patterns are major drivers of cardiometabolic dysfunction, partly mediated by gut microbiome dysbiosis and sustained inflammation along the gut–brain axis. In this study, we investigated whether a synbiotic formulation combining Limosilactobacillus ( L .) fermentum strains with polyphenols, quercetin, and resveratrol could mitigate cardiovascular and neuroinflammatory alterations induced by a Western diet. Male...

Saline stress negatively affects the physiological and biochemical functions of plants, inhibiting growth, the ability to perform photosynthesis, interfering with enzymatic activity, and protein and chlorophyll synthesis. Salicylic acid and jasmonic acid are two phytohormones involved in plant defense metabolism and have been used to mitigate the effects of salt stress in plants. In this context, the aim was evaluate whether t...

The combination of contaminated and fragmented habitat puts the most sensitive species at risk and can function as an ecological trap. Therefore, it is expected that forest birds that inhabit fragments surrounded by agricultural activities present some level of contamination by non-essential metals. Thus, this work sought to identify, using feathers, whether wild understory birds are contaminated by aluminum from sugarcane cro...

The Romualdo Formation, located in the Araripe Basin (NE, Brazil), represents an important sedimentary record of the late Aptian/early Albian transition, evidencing the establishment of a mixed siliciclastic–carbonate platform influenced by eustatic oscillations and marine ingressions associated with the breakup of Gondwana. Detailed analysis of thin sections from the Santo Antônio, Cedro, and Sobradinho sections revealed eigh...

Receptor Activity-Modifying Protein 1 (RAMP1) is a Calcitonin Receptor-Like Receptor (CALCRL)-associated protein with significant relevance in oncogenesis and tumor progression. It acts as a context-dependent allosteric modulator of GPCRs. This integrative review synthesizes evidence from multiple omics layers—transcriptomics, proteomics, epigenomics, and pan-cancer datasets—to clarify the role of RAMP1, its signaling pathways...

Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...

This study assessed the effects of dietary shrimp head meal (SHM) on growth performance, metabolism, antioxidant status, and health of Nile tilapia ( Oreochromis niloticus ) fingerlings. Five isonitrogenous and isoenergetic diets were precisely formulated on a digestible nutrient basis, containing graded SHM levels (0, 5, 10, 15, and 20%), and fed for 45 days to fish (3.24 ± 0.07 g) reared in 50 L tanks (10 fish tank −1 ; four...