The modern use of neoadjuvant and conversion systemic therapy in patients with colorectal cancer liver metastasis (CRLM) has improved resection rates and changed the borders between “resectable” and “unresectable” disease. Also, the use of preoperative systemic therapy has resulted in an increased frequency of disappearing liver metastasis (DLM). The optimal management of DLM is still controversial. In this review, we explore...

Meniscus injuries are widespread and the available treatments do not offer enough healing potential. Here, we provide critical support for using pigs as a biological model for meniscal degeneration and the development of cutting-edge therapies in orthopedics. We present a single-cell transcriptome atlas of the meniscus, consisting of cell clusters corresponding to four major cell types: chondrocytes, endothelial cells, smooth...

Aim Ecologically similar species living in sympatry are expected to segregate to reduce the effects of competition where resources are limiting. Segregation from heterospecifics commonly occurs in space, but it is often unknown whether such segregation has underlying environmental causes. Indeed, species could segregate because of different fundamental environmental requirements (i.e., ‘niche divergence’), because competitive...

Reduced cerebrovascular response to neuronal activation is observed in patients with neurodegenerative disease. In the present study, we examined the correlation between reduced cerebrovascular response to visual activation (ΔCBF Vis.Act ) and subclinical cognitive deficits in a human population of mid-sixties individuals without neurodegenerative disease. Such a correlation would suggest that impaired cerebrovascular function...

Aim In migratory species, individuals often use fixed and individual‐specific migration strategies, which we term individual migration strategy fidelity (IMSF). Our goal was to test if guillemots have flexible or fixed individual migration strategies (i.e. IMSF), if this behaviour is consistent across large parts of the genus’ range and if they were philopatric to geographical sites or a habitat feature. Location North Atlanti...