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Fetal pneumonia and polyarthritis associated with Ureaplasma diversum infection in an aborted beef cattle fetus in BrazilNARA Subscribed
Ureaplasma diversum is an opportunistic bovine pathogen associated with reproductive disorders, including infertility, granular vulvovaginitis, placentitis, and abortion; however, detailed descriptions of fetal osteoarticular lesions remain exceptionally uncommon. This report describes the gross, histopathological, and molecular findings of a bovine abortion associated with U. diversum infection presenting with concurrent pulm...
Interplay between CDH1 polymorphisms, haplotypes, and genomic repetitive elements in urothelial bladder cancer prognosisNARA Subscribed
Background Urothelial Bladder Cancer (UBC) remains a significant clinical challenge due to its high morbidity, substantial economic burden, and high recurrence rates. E-cadherin, an important regulator of cell-cell adhesion encoded by the CDH1 gene, is frequently downregulated during malignant progression, serving as a hallmark of invasiveness. This study explored the prognostic significance of CDH1 genetic variants (rs16260 C...
Glypican-4 (GPC-4), an endothelial cell surface protein, is released into the circulation in the context of ischemia, inflammation, neurohumoral activity, and shear stress. This study aimed to investigate the prognostic value of GPC-4 in chronic heart failure. GPC-4 concentrations were determined in two prospective cohorts: patients with chronic heart failure with reduced ejection fraction (HFrEF), and with transthyretin amylo...
Search for Equus caballus papillomavirus type 2 in tissues of asymptomatic horses in southern brazilNARA Subscribed
Equus caballus papillomavirus type 2 (EcPV-2) has been recently associated with the development of genital squamous cell carcinomas in horses. Nevertheless, its circulation among healthy, asymptomatic horses remains poorly understood. This study aimed to investigate the presence of EcPV-2 DNA in asymptomatic horses submitted to necropsy in southern Brazil. A total of 54 horses without clinical or histological evidence of genit...
Brazil is a country with an approximate 50% prevalence rate of carbapenem-resistant Pseudomonas aeruginosa (CR-PA). Therefore, monitoring the spread of high-risk clones from complex genotypes of CR-PA isolates is crucial for developing effective strategies to control antimicrobial resistance. In the present study, we aimed to evaluate the dissemination of high-risk clones P. aeruginosa carrying bla KPC-2 in Brazil. In this stu...
Macrophage modulation accounts for the anti-inflammatory effect of Hypnea cervicornis agglutinin in rat arthritis induced by zymosanNARA Subscribed
Previous study demonstrated that Hypnea cervicornis lectin (HCA) reduces inflammation and nociception via interaction with the lectin carbohydrate-binding site, modulating gene expression of the interleukins IL-1β, TNF-α and of iNOS. This study evaluated the effect of HCA in the rat model of arthritis induced by zymosan in the tibiotarsal joint and the involvement of macrophage-derived mediators. In vitro, macrophages were sti...
Biological control mitigates oxidative stress induced by Tetranychus urticae (Koch) (Acari: Tetranychidae) in cucumber plantsNARA Subscribed
Intensive cucumber cultivation favors the occurrence of pests, particularly Tetranychus urticae (Koch) (Acari: Tetranychidae), which causes damage to leaf tissues, impairing photosynthesis and cellular integrity. Management of this pest is commonly based on chemical control; however, this strategy may intensify oxidative stress in plants. In this context, biological control emerges as a sustainable alternative. This study aime...