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Springer Nature1
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Pharmaceutical Research1
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20251
Maria Miclaus results 1 · Newest (Page 1/1, per page 25)
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Pharmaceutical Co-crystal of Ketoconazole-adipic Acid: Excipient Compatibility and In Silico Antifungal Potential StudiesNARA Subscribed
Pharmaceutical Research · 2025 · Vol. 42 · Issue 9 · Springer
Flavia Martin; Maria Miclaus; Ana Maria Raluca Gherman; Monica Dan; Ioana Grosu; Xenia Filip; Irina Kacso
Objective This research aimed to investigate the compatibility of the Ketoconazole-Adipic Acid (KTZ-AA) co-crystal, which exhibits an improved dissolution profile over pure Ketoconazole, with various solid pharmaceutical excipients, as well as its in silico antifungal potential. Methods Binary physical mixtures (1:1 w/w) of KTZ-AA co-crystal and excipients were analyzed using differential scanning calorimetry (DSC), thermograv...
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