Complex cell culture systems are increasingly being used to study host-pathogen interactions with high physiological relevance. In contrast to monolayer cultures, organoids, differentiated tissue models, and organ-on-chip platforms better reproduce tissue architecture and barrier function, key determinants of infection processes. While challenges remain, such as immune cell integration, ongoing methodological advances are expe...

There is an urgent need for countries to transition their national food and land-use systems toward food and nutritional security, climate stability, and environmental integrity. How can countries satisfy their demands while jointly delivering the required transformative change to achieve global sustainability targets? Here, we present a collaborative approach developed with the FABLE—Food, Agriculture, Biodiversity, Land, and...

Diabetic polyneuropathy (DPN) is the most common complication in diabetes and can be painful in up to 26% of all diabetic patients. Peripheral nerves are shielded by the blood-nerve barrier (BNB) consisting of the perineurium and endoneurial vessels. So far, there are conflicting results regarding the role and function of the BNB in the pathophysiology of DPN. In this study, we analyzed the spatiotemporal tight junction protei...