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Western Hunter-Gatherer genetic ancestry contributes to human longevity in the Italian populationNARA Subscribed
The genetics of human longevity has been primarily studied using classical methods developed in genome-wide association studies. With the recent advances in paleogenomics, it is now possible to investigate to what extent ancient population ancestries contribute to complex traits. In this study, we explored the role of ancient genetic components in human longevity by focusing on the Italian Peninsula, whose genetic heritage inc...
Microplastics in the menu of Mediterranean zooplankton: Insights from the feeding response of the calanoid copepod Centropages typicusNARA Subscribed
Microplastic input into the ocean represents an increasing threat to marine biota and may endanger the functioning of marine ecosystems, especially in semi‐enclosed basins, such as the Mediterranean Sea. The size spectrum of microplastics overlaps with that of nano‐microplankton (2–200 μm), thus potentially misleading suspension‐feeding zooplankton, which represent a key trophic link in pelagic food webs. We investigated the e...
Coastal mesozooplankton respond to decadal environmental changes via community restructuringNARA Subscribed
Long‐term ecological research has revealed the impact of climate on marine ecosystems at multiple time scales. Changes in the pelagic system have been detected at the LTER‐MC site in the Gulf of Naples (Tyrrhenian Sea, western Mediterranean) since 1984. Here we analyzed the time series to determine whether zooplankton had significantly changed over the three decades 1984–2015. In addition to the seasonal cycle as the main mode...
Histone deacetylases (HDAC) are enzymes that regulate the concentration of acetylated histones which, in turns, interact with the bromodomain (BRD) of BET (Bromodomain and Extracellular domain) proteins to affect transcriptional activity. Simultaneous blockade of both epigenetic players has shown synergistic effects in a variety of cancer cell lines. In this paper we report the design, synthesis and activity of new dual inhibi...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
The green–blue swing: plasticity of plankton food‐webs in response to coastal oceanographic dynamicsNARA Subscribed
The internal organization of plankton communities plays a key role in biogeochemical cycles and in the functioning of aquatic ecosystems. In this study, the structure of a marine plankton community (including both unicellular and multicellular organisms) was inferred by applying an ecological network approach to species abundances observed weekly at the long‐term ecological research station M are C hiara ( LTER ‐ MC ) in the G...
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