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NARA Subscribed1
Publisher
Springer Nature1
Journal
Stem Cell Reviews and Reports1
Publication Year
20221
Maria Velascode Andres results 1 · Newest (Page 1/1, per page 25)
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Comparison of Single and Repeated Dosing of Anti-Inflammatory Human Umbilical Cord Mesenchymal Stromal Cells in a Mouse Model of Polymicrobial SepsisNARA Subscribed
Stem Cell Reviews and Reports · 2022 · Vol. 18 · Issue 4 · Springer
Barbara Fazekas; Senthilkumar Alagesan; Luke Watson; Olivia Ng; Callum M. Conroy; Cristina Català; Maria Velascode Andres; Neema Negi; Jared Q. Gerlach; Sean O. Hynes; Francisco Lozano; Stephen J. Elliman; Matthew D. Griffin
Summary Mesenchymal stromal cells (MSCs) ameliorate pre-clinical sepsis and sepsis-associated acute kidney injury (SA-AKI) but clinical trials of single-dose MSCs have not indicated robust efficacy. This study investigated immunomodulatory effects of a novel MSC product (CD362-selected human umbilical cord-derived MSCs [hUC-MSCs]) in mouse endotoxemia and polymicrobial sepsis models. Initially, mice received intra-peritoneal (...
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