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This study evaluated the effectiveness of sewage sludge biochar (SSB) produced at 350, 450, and 600 °C for immobilizing potentially toxic elements (PTEs) in a tropical multi-contaminated Vertisol. Chromium, copper, cobalt, nickel, cadmium, lead, and zinc were assessed through sequential extraction, ecological risk indices, and principal component analysis (PCA). Pyrolysis temperature markedly altered biochar properties and, co...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Distribution, scale, and drivers of mass mortality events in Europe's freshwater bivalvesNARA Subscribed
Mass mortality events (MMEs) are decimating populations and compromising key ecosystem functions around the globe. One taxon particularly vulnerable to MMEs is freshwater bivalve mollusks. This group has important ecosystem engineering capacities and includes highly threatened and highly invasive taxa. Thus, MMEs of freshwater bivalves have important implications for conservation and ecosystems. Despite this, little is known a...
The effects of one-night sleep deprivation and one-night recovery sleep on endurance cycling performanceNARA Subscribed
Purpose Sleep deprivation (SD) seems to impair endurance performance. However, little research is available on the effects of SD in the context of repeated bouts of endurance exercise. The effect of recovery sleep on endurance performance is also poorly understood. Methods Twenty-six male amateur cyclists/triathletes (mean ± SD: age 30.5 ± 8.8 yr, $$\dot{\text{V}}{\mathrm{O}}$$ V ˙ O 2peak 55.3 ± 4.9 mL/kg/min) were randomly a...
Despite their potential to inform sustainable regional harvest and climate‐resilient fisheries management, spatial stock assessment models remain underused for management advice. To identify barriers that inhibit broader use of these methods, we conducted a blinded international simulation experiment mimicking real‐world stock assessment development when confronting spatial complexity. Seven analyst teams built spatially aggre...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
The protection of the Vulnerable Marine Ecosystem identified by the presence of the critically endangered bamboo coral Isidella elongata has been recognized as an urgent task. Although some research has focused on the spatial distribution of this species, there is no information available on its connectivity and genetic structure. This is the first study to examine the genetic diversity pattern and inter-population connectivit...
Marine sterols from brown seaweeds, particularly fucosterol and its oxidized derivative saringosterol, have shown therapeutic potential for Alzheimer’s disease (AD) and cardiovascular diseases. Here, we aimed to elucidate the cellular and in vivo mechanisms underlying their beneficial effects. In human HepG2 hepatocytes and CCF-STTG1 astrocytoma cells, we assessed liver x receptor (LXRα /LXRβ) activation, sterol uptake, and ef...