Background Lobaric and rhizocarpic acids are secondary metabolites isolated from Antarctic lichens. While several biological activities have been described for lobaric acid, the cellular effects of rhizocarpic acid remain poorly characterized. This study investigated the impact of these compounds on proliferation, apoptosis, and cell cycle regulation in human leukemic cell models. Methods and Results Human leukemic K562 and MO...

Gentiana lutea roots have been widely used in the traditional medicine, especially for their stomachic properties. In this study, the effect of G. lutea root methanol extract on SH-SY5Y cell survival and on anti-proliferative activity of pro-apoptotic agents was evaluated. In neuroblastoma cell line SH-SY5Y, the extract did not exhibit any cytotoxic activity, but protected cells from vinblastine-induced apoptosis. In the combi...