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NARA Subscribed1
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Springer Nature1
Journal
Inflammopharmacology1
Publication Year
20231
Mariam Bassem results 1 · Newest (Page 1/1, per page 25)
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Neuromodulatory effect of vardenafil on aluminium chloride/d-galactose induced Alzheimer’s disease in rats: emphasis on amyloid-beta, p-tau, PI3K/Akt/p53 pathway, endoplasmic reticulum stress, and cellular senescenceNARA Subscribed
Inflammopharmacology · 2023 · Vol. 31 · Issue 5 · Springer
Heba H. Awad; Mahmoud A. Desouky; Alaa Zidan; Mariam Bassem; Amaal Qasem; Mona Farouk; Haidy AlDeab; Miral Fouad; Cherry Hany; Nada Basem; Rita Nader; Ashrakat Alkalleny; Verina Reda; Mina Y. George
Dysregulation of protein homeostasis, proteostasis, is a distinctive hallmark of many neurodegenerative disorders and aging. Deleteriously, the accumulation of aberrant proteins in Alzheimer’s disease (AD) is accompanied with a marked collapse in proteostasis network. The current study explored the potential therapeutic effect of vardenafil (VAR), a phosphodiesterase-5 inhibitor, in AlCl 3 / d -galactose ( d -gal)-induced AD i...
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