Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...

The rainy season is of high importance for livelihoods in the Southern Peruvian Andes (SPA), especially for agriculture, which is mainly rain fed and one of the main income sources in the region. Therefore, knowledge and predictions of the rainy season such as its onset and ending are crucial for planning purposes. However, such information is currently not readily available for the local population. Moreover, an evaluation of...

In the southern Peruvian Andes, communities are highly dependent on climatic conditions due to the mainly rain‐fed agriculture and the importance of glaciers and snow melt as a freshwater resource. Longer‐term trends and year‐to‐year variability of precipitation or temperature severely affect living conditions. This study evaluates seasonal precipitation and temperature climatologies and trends in the period 1965/66–2017/18 fo...

In situ climatological observations are essential for studies related to climate trends and extreme events. However, in many regions of the globe, observational records are affected by a large number of data quality issues. Assessing and controlling the quality of such datasets is an important, often overlooked aspect of climate research. Besides analysing the measurement data, metadata are important for a comprehensive data q...