Ivermectin (IV), a commonly used antiparasitic drug for livestock and humans, eventually finds its way into aquatic environments, primarily through fecal matter and livestock carcasses. The presence of IV in water bodies may pose a risk to non-target aquatic organisms, such as phytoplankton, whose primary habitat is the aquatic environment. The adverse effects of IV may be exacerbated by its interactions with organic matter an...

Selective autophagy requires precise spatial organization to recognize and degrade cellular cargo. We recently found that low-affinity cargo-receptor interactions preserve receptor mobility, enabling formation of initiation hubs, phase-separated assemblies that drive autophagosome biogenesis. These findings suggest autophagy is not only a linear pathway but also guided by physical principles such as wetting, phase separation a...