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Aging is associated with blood–brain barrier (BBB) breakdown and microvascular rarefaction, key contributors to cerebral neuroinflammation, hypoperfusion, and vascular cognitive impairment and dementia (VCID). Exposure to a young systemic milieu through heterochronic parabiosis has been shown to restore BBB integrity and enhance cerebrovascular function in aged mice, suggesting that circulating factors can rejuvenate the aging...
The Asia region harbors exceptional chondrichthyan (shark, ray, and chimaera) diversity but faces intense fishing pressure. The Important Shark and Ray Areas (ISRA) process provides a collaborative, evidence-based framework to identify critical habitats and inform spatial management. We assessed ISRAs across the Bay of Bengal, Southeast Asia, and the Northwest Pacific to characterize their extent, ecological significance, and...
The purpose of this study was to investigate the prevalence of relative age effects (RAEs) within and between U18, U21 and professional senior squads, that compete in the highest (respective) leagues within England. Birthdate, playing position and age (years) of U18 ( n = 487), U21 ( n = 350), and senior ( n = 396) players from squads competing in the highest divisions of their respective age groups were obtained. Moreover, na...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Local and Landscape‐Level Environmental Conditions Drive Habitat Selection Across Terrestrial Mammal SpeciesNARA Subscribed
Aim Animal movements are a fundamental process affecting communities and ecosystems. Quantifying habitat selection across species and habitats is key for understanding how animals respond to environmental change. Currently, we lack comparative studies that examine how habitat selection varies across species traits and landscapes. We aim to quantify global patterns of habitat selection to help understand the fundamental drivers...
Unprecedented Burning in Tropical Peatlands During the 20th Century Compared to the Previous Two MillenniaNARA Subscribed
Tropical peatland wildfire incidence has risen in recent decades, driven by drainage for land use and intensified by severe droughts with global climate change. These disturbances have altered vegetation structure, disrupted ecosystem functioning, and increased carbon emissions, particularly in Southeast Asia. However, the long‐term history and characteristics of wildfires in tropical peatlands remain largely unknown. Here, we...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Angler demographics and motivations are an important consideration to successful fisheries management. We examined 29 years of angler license and activity records from the recreational Atlantic salmon fishery in Newfoundland and Labrador, Canada to: (1) provide a contemporary evaluation of angler demographic trends; (2) evaluate age and regional differences between anglers who prioritized retention versus catch‐and‐release; an...
The grey wolf exemplifies ecological resilience, having survived major climatic fluctuations since the Middle Pleistocene. Once the world's most widely distributed mammal, its range has been drastically reduced by human‐driven habitat loss, persecution and competition for resources. Although listed as of Least Concern globally by the IUCN, the omission of climate change as a threat raises critical questions about its future pe...