Mark Baker results 106
· Newest (Page 1/5, per page 25)
Author: Mark Baker ×Clear All Filters
Search Results
Barriers and facilitators to implementing the European code of cancer practice in a rural and coastal setting: a qualitative studyNARA Subscribed
Purpose The European Code of Cancer Practice (ECCP) is a patient-centred framework for good clinical cancer practice, to improve outcomes for all of Europe’s patients [1]. Given challenges with applications to rural regions, the study aimed to explore the barriers and facilitators to implementing the ECCP in a rural, coastal, and urban context. Methods We conducted semi-structured individual and group interviews with nine acut...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Success of restoration strategies in preventing extirpation of 2 critically endangered coral speciesNARA Subscribed
An unprecedented marine heatwave in 2023 caused widespread coral bleaching and mortality throughout the Caribbean. In the Florida Keys (USA), 2 foundation species, elkhorn coral ( Acropora palmata ) and staghorn coral ( Acropora cervicornis ), were severely affected. These species have been the primary focus of reef restoration in Florida for decades. Substantial losses of these species occurred in outplanted populations, in o...
The fertility of a sub-population of stallions is negatively affected by ambient climatic conditions, mediated through DNA damageNARA Subscribed
Exposure to systemic heat stress in male mammals adversely affects sperm production, fertility, and DNA integrity. To date, few studies have investigated this phenomenon in horses, particularly in industry-relevant environments. Therefore, this study examined the relationship between ambient climatic conditions and fertility within a population of commercially fertile stallions. Post-coital semen samples ( n = 804) were collec...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Polymyxins remain indispensable last-line antibiotics for multidrug-resistant Gram-negative infections, yet their clinical use in central nervous system (CNS) infections is constrained by poorly understood neurotoxicity. Here, we define the early molecular signalling events underlying polymyxin B-induced CNS toxicity using an integrated phosphoproteomic and Reverse Phase Protein Array (RPPA) approach in rat brain following int...
The Evolution of Southern Ocean Net Primary Production in a Changing Climate: Challenges and OpportunitiesNARA Subscribed
Net primary production in the Southern Ocean plays a critical role in governing ecosystem production, the biological carbon pump, and global biogeochemical cycles. Recent work has advanced our understanding of novel factors regulating Southern Ocean net primary production and the regional physiological adaptations employed by Southern Ocean phytoplankton in terms of their photosynthetic strategies and resource acquisition. Her...
Accounting for human–nature linkages in area‐based conservation monitoring through social–ecological indicator bundlesNARA Subscribed
As the coverage of area‐based conservation increases across the globe, it is critical to improve understanding of the social and ecological outcomes of such measures and the pathways to their outcomes. A social–ecological systems approach to monitoring and evaluation is increasingly advocated; yet, applications remain scarce. We sought to facilitate operationalization of this approach through prioritization of indicators when...
Association of a kinematic measure of upper limb reaching and StartReact in chronic hemiparetic strokeNARA Subscribed
Background After stroke, recovery of upper limb reaching movements may partly depend on the level of activation of the reticulospinal tract (RST), but few clinical studies have explored this. Here we examined the association between the strength of reticulospinal connections and extent of reaching in post-stroke patients. Methods Fifteen patients (all male) with right hemiparesis who had suffered a stroke at least six months p...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...