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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Defining an ageing-related pathology, disease or syndrome: International Consensus StatementNARA Subscribed
Around the world, individuals are living longer, but an increased average lifespan does not always equate to an increased health span. With advancing age, the increased prevalence of ageing-related diseases can have a significant impact on health status, functional capacity and quality of life. It is therefore vital to develop comprehensive classification and staging systems for ageing-related pathologies, diseases and syndrom...
DNA metabarcoding identifies urban foraging patterns of oligolectic and polylectic cavity-nesting beesNARA Subscribed
Urbanisation modifies natural landscapes resulting in built-up space that is covered by buildings or hard surfaces and managed green spaces that often substitute native plant species with exotics. Some native bee species have been able to adapt to urban environments, foraging and reproducing in these highly modified areas. However, little is known on how the foraging ecology of native bees is affected by urbanised environments...
Exploring controls of the early and stepped deglaciation on the western margin of the British Irish Ice SheetNARA Subscribed
New optically stimulated luminescence dating and Bayesian models integrating all legacy and BRITICE‐CHRONO geochronology facilitated exploration of the controls on the deglaciation of two former sectors of the British–Irish Ice Sheet, the Donegal Bay (DBIS) and Malin Sea ice‐streams (MSIS). Shelf‐edge glaciation occurred ~27 ka, before the global Last Glacial Maximum, and shelf‐wide retreat began 26–26.5 ka at a rate of ~18.7–...
Predicting the future response of ice sheets to climate warming and rising global sea level is important but difficult. This is especially so when fast‐flowing glaciers or ice streams , buffered by ice shelves, are grounded on beds below sea level. What happens when these ice shelves are removed? And how do the ice stream and the surrounding ice sheet respond to the abruptly altered boundary conditions? To address these questi...
Retreat dynamics of the eastern sector of the British–Irish Ice Sheet during the last glaciationNARA Subscribed
The findings of BRITICE‐CHRONO Transect 2 through the North Sea Basin and eastern England are reported. We define ice‐sheet marginal oscillation between ~31 and 16 ka, with seven distinctive former ice‐sheet limits (L1–7) constrained by Bayesian statistical analysis. The southernmost limit of the North Sea Lobe is recorded by the Bolders Bank Formation (L1; 25.8–24.6 ka). L2 represents ice‐sheet oscillation and early retreat t...
The evolution of the terrestrial‐terminating Irish Sea glacier during the last glaciationNARA Subscribed
Here we reconstruct the last advance to maximum limits and retreat of the Irish Sea Glacier (ISG), the only land‐terminating ice lobe of the western British Irish Ice Sheet. A series of reverse bedrock slopes rendered proglacial lakes endemic, forming time‐transgressive moraine‐ and bedrock‐dammed basins that evolved with ice marginal retreat. Combining, for the first time on glacial sediments, optically stimulated luminescenc...
Pattern, style and timing of British–Irish Ice Sheet retreat: Shetland and northern North Sea sectorNARA Subscribed
The offshore sector around Shetland remains one of the least well‐studied parts of the former British–Irish Ice Sheet with several long‐standing scientific issues unresolved. These key issues include (i) the dominance of a locally sourced ‘Shetland ice cap’ vs an invasive Fennoscandian Ice Sheet; (ii) the flow configuration and style of glaciation at the Last Glacial Maximum (i.e. terrestrial vs marine glaciation); (iii) the n...
Sedimentation during Marine Isotope Stage 3 at the eastern margins of the Glacial Lake Humber basin, EnglandNARA Subscribed
The stratigraphic sequence at North Cave, on the eastern margins of the Lake Humber basin, records the deposition of a fluvioperiglacial fan (LFs 1–4), with early sedimentation (LF1) dating to Marine Isotope Stage (MIS) 3 (optically stimulated luminescence date range 41.8–38.6 ka and 14 C dates 41.6–49 ka BP). Three phases of permafrost and ice wedge development during MIS 3 are evident and indicate possible fan abandonment an...
Glacial Lake Pickering: stratigraphy and chronology of a proglacial lake dammed by the North Sea Lobe of the British–Irish Ice SheetNARA Subscribed
We report the first chronology, using four new optically stimulated luminescence dates, on the sedimentary record of Glacial Lake Pickering, dammed by the North Sea Lobe of the British–Irish Ice Sheet during the Dimlington Stadial (24–11 ka cal BP). Dates range from 17.6 ± 1.0 to 15.8 ± 0.9 ka for the sedimentation of the Sherburn Sands at East Heslerton, which were formed by multiple coalescing alluvial fans prograding into t...
A late Pleistocene–Holocene multi‐proxy record of palaeoenvironmental change from Still Bay, southern Cape Coast, South AfricaNARA Subscribed
The southern Cape is a key focus for southern African palaeoenvironmental research as it represents the transitional region between temperate westerlies and sub‐tropical rainfall sources. This study presents pollen, plant biomarker, geochemical and charcoal data preserved in the Rietvlei wetland. The bulk of the record spans the last 16 ka, but it also provides rare insights into late Marine Oxygen Isotope Stage (MIS) 3 (ca. 3...
Archaeological investigations undertaken along a proposed highway together with the compilation of available geological and pedological data made it possible to give a first overview of the distribution of Pleistocene aeolian deposits in south‐west France. A chronological framework for deposition has been obtained using both radiocarbon ( n = 24) and luminescence ( n = 26) dating. It shows that aeolian transport was very activ...
Understanding geomorphic responses to environmental change: a 19 000‐year case study from semi‐arid central Texas, USANARA Subscribed
Understanding the impact of past climatic changes on landscape stability is crucial in order to predict and mitigate the effects of future changes. However, in arid and semi‐arid environments, reconstructions are often hampered by a poor understanding of the relationship between sediment deposition and climate. We present here data from central Texas, a region that is sensitive to environmental change but has received relative...
Luminescence dating indicates radiocarbon age underestimation in late Pleistocene fluvial deposits from eastern EnglandNARA Subscribed
Robust geochronological control is crucial for interpreting and correlating the environmental record from fragmentary terrestrial sequences from the last glacial period. Traditional terrestrial stratigraphies are typically reliant on radiocarbon dating, although estimates of antiquity for samples older than 40 ka may be unreliable. Optically stimulated luminescence (OSL) dating of sediments is an alternative for dating the who...
First evidence for episodic flooding events in the arid interior of central Saudi Arabia over the last 60 kaNARA Subscribed
Although evidence for Quaternary environmental changes in the Arabian Peninsula is now growing, research has mostly been conducted in the United Arab Emirates (UAE) and in the Sultanate of Oman. There have been virtually no recent studies in Saudi Arabia, especially in the central region such as around Al‐Quwaiayh. In this area there are a series of outwash plains developed along the eastern edge of the Arabian Shield that for...
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