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Methods for investigating trace metal speciation and partitioning in mangrove sediments: a systematic quantitative literature reviewNARA Subscribed
Purpose Mangrove rhizosphere sediments are strong sinks for trace metals, yet conventional sampling and analytical approaches often lack the resolution to capture the fine-scale biogeochemical processes driving metal immobilisation. This review evaluates the limitations of common methodologies used to study trace metal speciation and partitioning in mangrove sediments and provides recommendations for best practices. Methods A...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Anthropogenic change has resulted in pollinator declines and altered plant–pollinator interactions. This may alter pollination services, reducing the reproductive success of plants. Yet few datasets allow us to track changes in pollination services over time. Herbaria provide a unique opportunity to assess pollination services across broad spatial and temporal scales enabling the examination of associated spatiotemporal anthro...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Accounting for human–nature linkages in area‐based conservation monitoring through social–ecological indicator bundlesNARA Subscribed
As the coverage of area‐based conservation increases across the globe, it is critical to improve understanding of the social and ecological outcomes of such measures and the pathways to their outcomes. A social–ecological systems approach to monitoring and evaluation is increasingly advocated; yet, applications remain scarce. We sought to facilitate operationalization of this approach through prioritization of indicators when...
BMP9 knockout impairs pulmonary vessel muscularisation and confers aberrant tamoxifen sensitivityNARA Subscribed
Deleterious mutations in the GDF2 gene, encoding BMP9, are causative of pulmonary arterial hypertension and hereditary haemorrhagic telangiectasia. Paradoxically, BMP9 germ-line knockout ( Gdf2 −/− ; Bmp9 KO) and double Bmp9 KO / conditional Bmp10 cKO (dKO) mice exhibit an attenuated response to PAH-inducing stimuli. We asked whether this contradiction is due to the pathological, physiological, or genetic consequences of BMP9...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Inequity is ubiquitous in the ocean, and social equity receives insufficient attention in ocean governance and management efforts. Thus, we assert that proponents of sustainability must center social equity in future ocean governance, to address past social and environmental injustices, to align with international law and conservation policy, and to realize objectives of sustainability. This obligation applies across all marin...
Land use change threatens global biodiversity and compromises ecosystem functions, including pollination and food production. Reduced taxonomic α‐diversity is often reported under land use change, yet the impacts could be different at larger spatial scales (i.e., γ‐diversity), either due to reduced β‐diversity amplifying diversity loss or increased β‐diversity dampening diversity loss. Additionally, studies often focus on taxo...
Knowledge co-production for identifying indicators and prioritising solutions for food and land system sustainability in AustraliaNARA Subscribed
Achieving sustainable Australian food and land systems requires the rapid implementation and scaling up of a broad suite of solutions to meet the Sustainable Development Goals (SDGs). Decision-making frameworks are needed to identify suitable indicators and prioritise solutions at national scales to inform sustainability transitions. Using a knowledge co-production framework, we convened 150 stakeholders from 100 + organisatio...
Sicklefin (Macrhybopsis meeki) and sturgeon chub (M. gelida) historically occurred throughout the Missouri River (MR), in some tributaries, and Mississippi River downstream of the MR. They have been species of U.S. state-level conservation concern and U.S. Endangered Species Act listing candidates since the 1990s. We applied analytical approaches from occupancy modeling to correlation to monitoring data spanning 23 years to as...