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Springer Nature1
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Molecular and Cellular Biochemistry1
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20201
Mark Busbridge results 1 · Newest (Page 1/1, per page 25)
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Hepcidin secretion was not directly proportional to intracellular iron-loading in recombinant-TfR1 HepG2 cells: short communicationNARA Subscribed
Molecular and Cellular Biochemistry · 2020 · Vol. 468 · Issue 1-2 · Springer
Kosha J. Mehta; Mark Busbridge; Vinood B. Patel; Sebastien Je. Farnaud
Hepcidin is the master regulator of systemic iron homeostasis and its dysregulation is observed in several chronic liver diseases. Unlike the extracellular iron-sensing mechanisms, the intracellular iron-sensing mechanisms in the hepatocytes that lead to hepcidin induction and secretion are incompletely understood. Here, we aimed to understand the direct role of intracellular iron-loading on hepcidin mRNA and peptide secretion...
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