Mark Fuller results 35
· Newest (Page 1/2, per page 25)
Author: Mark Fuller ×Clear All Filters
Search Results
Exploring the data demands and global opportunities for reconstructing morphological responses to climate changeNARA Subscribed
There is growing evidence that morphological change is a widespread response to the warming climate. The empirical basis for understanding this process has, to date, largely been correlative analyses of morphological time series. However, it is not clear what constitutes sufficient temporal sampling for assessing long-term morphological change. We analyzed two long-term high-quality morphological datasets, one including 33 spe...
For large-scale tropical tuna purse-seine fisheries, it is prohibitively costly to obtain adequate sampling coverage to estimate fleet-level catch composition solely from sample data. Logbook or observer data, with complete fleet coverage, are often available but may be considered unreliable for species composition. Previous studies have developed models, trained with sample data, to predict set-level species compositions base...
Aim Eucalypt species are known for their diversity of bark types and adaptation to fire and drought. Eucalypts with stringy bark and ribboning bark are notorious for accumulating large amounts of bark fuels compared to other tree species. In this study, we examined the fire regime (fire frequency and intensity) and bioclimatic distributions of 12 contrasting eucalypt bark types, and provided maps of eucalypt bark type distribu...
SNAPSHOT USA 2019–2023: The First Five Years of Data From a Coordinated Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multicontributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of specie...
‘Rainier Russet’ was released in 2020 as a medium- to late-maturing selection with russeted tubers. Total yields are less, but similar to controls ‘Ranger Russet’ and ‘Russet Burbank’, and U.S. No. 1 yields are higher than Russet Burbank with increased tubers > 284 g. Compared to controls, it has high protein levels, high specific gravity, excellent fry color and flavor ratings, low acrylamide potential, good post-harvest meri...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Development of a Once-Daily Modified-Release Formulation for the Short Half-Life RIPK1 Inhibitor GSK2982772 using DiffCORE TechnologyNARA Subscribed
Purpose GSK2982772 is a selective inhibitor of receptor-interacting protein kinase-1 (RIPK1) with a short 2- to 3-h half-life. In a previous modified-release (MR) study, a matrix monolithic formulation (80% GSK2982772 released over 12 h) provided a once-daily (QD) pharmacokinetic (PK) profile in the fasted state; however, it was susceptible to food effects. The current study evaluated the safety and PK of MR formulations using...
Development of a Prototype, Once-Daily, Modified-Release Formulation for the Short Half-Life RIPK1 Inhibitor GSK2982772NARA Subscribed
Purpose GSK2982772 is a selective inhibitor of receptor-interacting protein kinase-1, with a 2–3 h half-life. This study evaluated if a once-daily modified-release formulation of GSK2982772 could be developed with no significant food effect. Methods Part A evaluated the pharmacokinetics of GSK2982772 following fasted single-dose (120 mg) administration of two matrix minitab formulations (MT-8 h and MT-12 h) vs 120 mg immediate...
With the accelerating pace of global change, it is imperative that we obtain rapid inventories of the status and distribution of wildlife for ecological inferences and conservation planning. To address this challenge, we launched the SNAPSHOT USA project, a collaborative survey of terrestrial wildlife populations using camera traps across the United States. For our first annual survey, we compiled data across all 50 states dur...
Microplastic ingestion ubiquitous in marine turtlesNARA Subscribed
Despite concerns regarding the environmental impacts of microplastics, knowledge of the incidence and levels of synthetic particles in large marine vertebrates is lacking. Here, we utilize an optimized enzymatic digestion methodology, previously developed for zooplankton, to explore whether synthetic particles could be isolated from marine turtle ingesta. We report the presence of synthetic particles in every turtle subjected...