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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Local and Landscape‐Level Environmental Conditions Drive Habitat Selection Across Terrestrial Mammal SpeciesNARA Subscribed
Aim Animal movements are a fundamental process affecting communities and ecosystems. Quantifying habitat selection across species and habitats is key for understanding how animals respond to environmental change. Currently, we lack comparative studies that examine how habitat selection varies across species traits and landscapes. We aim to quantify global patterns of habitat selection to help understand the fundamental drivers...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Both local and global climate phenomena shape the hydrologic regimes of watersheds. For aridland rivers in the southwestern United States, peak flows occur during two distinct periods: spring snowmelt and summer monsoons. Although discharge ( Q ) is a primary driver of variation in the production and consumption of instream organic matter, or stream metabolism, few connection have been made regarding how climate impacts ecosys...
The Gulf of Mexico’s (also recognized by the United States government as the Gulf of America; herein referred to as “the Gulf”) valuable and diverse marine, coastal, and estuarine environments sustain many habitats, species, and economically important fisheries that are vulnerable to open ocean and coastal acidification (OOCA), including shellfish, coral reefs, and other carbonate reefs and seafloor. OOCA poses an economic thr...
Discovering a predictive metabolic signature of drug-induced structural cardiotoxicity in cardiac microtissuesNARA Subscribed
Improved prediction of drug-induced structural cardiotoxicity is required to reduce attrition driven by cardiac safety concerns in drug discovery. Omics measurements are well suited to this need, offering the potential to discover molecular signatures associated with toxicological endpoints. In addition, untargeted metabolomics can simultaneously measure xenobiotic fate within the test system. We present an extensive metabolom...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Positive Feedback on Climate Warming by Stream Microbial Decomposers Indicated by a Global Space‐For‐Time Substitution StudyNARA Subscribed
Decomposition of plant litter is a key ecological process in streams, whose contribution to the global carbon cycle is large relative to their extent on Earth. We examined the mechanisms underlying the temperature sensitivity (TS) of instream decomposition and forecast effects of climate warming on this process. Comparing data from 41 globally distributed sites, we assessed the TS of microbial and total decomposition using lit...
Mortality in a cohort of WTC-exposed law-enforcement officers compared to non-WTC law-enforcement officersNARA Subscribed
Purpose World Trade Center (WTC) rescue/recovery workers were exposed to materials hazardous to health. Previous studies found lower than expected mortality among WTC rescue/recovery workers when compared to general populations, possibly due to healthy worker effects, better healthcare access and/or incomparability of the groups. We compared mortality rates in WTC-exposed law enforcement officers (LEOs) with rates in LEOs empl...
Postglacial Recolonization of the Southern Ocean by Elephant Seals Occurred From Multiple Glacial RefugiaNARA Subscribed
The Southern Ocean is warming more rapidly than other parts of our planet. How this region's endemic biodiversity will respond to such changes can be illuminated by studying past events through genetic analyses of time‐series data sets, including historic and fossil remains. Archaeological and subfossil remains show that the southern elephant seal ( Mirounga leonina ) was common along the coasts of Australia and New Zealand in...
Land use change threatens global biodiversity and compromises ecosystem functions, including pollination and food production. Reduced taxonomic α‐diversity is often reported under land use change, yet the impacts could be different at larger spatial scales (i.e., γ‐diversity), either due to reduced β‐diversity amplifying diversity loss or increased β‐diversity dampening diversity loss. Additionally, studies often focus on taxo...