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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Late Quaternary population expansion in gray brocket deer [ Subulo gouazoubira (G. Fisher, 1814), Cervidae, Mammalia] in BrazilNARA Subscribed
There is little information about the changes in the abundance of mammalian species in South America during the late Quaternary, which is a key parameter to understanding past ecological and evolutionary dynamics. Here, we describe a conspicuous increase in the abundance of the gray brocket deer ( Subulo gouazoubira G. Fisher, 1814; Mammalia) during the late Quaternary in Brazil based on paleontological evidence. We studied th...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Transdisciplinary Collaborations for Advancing Sustainable and Resilient Agricultural SystemsNARA Subscribed
Feeding the growing human population sustainably amidst climate change is one of the most important challenges in the 21st century. Current practices often lead to the overuse of agronomic inputs, such as synthetic fertilizers and water, resulting in environmental contamination and diminishing returns on crop productivity. The complexity of agricultural systems, involving plant‐environment interactions and human management, pr...
SNAPSHOT USA 2019–2023: The First Five Years of Data From a Coordinated Camera Trap Survey of the United StatesNARA Subscribed
Motivation SNAPSHOT USA is an annual, multicontributor camera trap survey of mammals across the United States. The growing SNAPSHOT USA dataset is intended for tracking the spatial and temporal responses of mammal populations to changes in land use, land cover and climate. These data will be useful for exploring the drivers of spatial and temporal changes in relative abundance and distribution, as well as the impacts of specie...
Particulate filters are state-of-the-art and are used in internal combustion engines worldwide to eliminate carcinogenic nanoparticles. Health studies estimate that this prevents about one million premature deaths annually. What is less known and often neglected is their equally powerful effect on mitigating global warming. This is because these ultrafine particles form stable aerosols in the atmosphere, absorb sunlight, and h...
Purpose We evaluated the safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of intravenous (IV) inclacumab, a fully human IgG4 anti–P-selectin monoclonal antibody in development for the treatment of sickle cell disease, at doses up to and exceeding those previously tested in healthy individuals. Methods In this phase 1, open-label, single-ascending-dose study, 15 healthy participants were enrolled into co...
Residence time determines invasiveness and performance of garlic mustard ( Alliaria petiolata ) in North AmericaNARA Subscribed
While biological invasions have the potential for large negative impacts on local communities and ecological interactions, increasing evidence suggests that species once considered major problems can decline over time. Declines often appear driven by natural enemies, diseases or evolutionary adaptations that selectively reduce populations of naturalised species and their impacts. Using permanent long‐term monitoring locations,...
Toll like-receptor agonist Pam3Cys modulates the immunogenicity of liposomes containing the tuberculosis vaccine candidate H56NARA Subscribed
A major roadblock in the development of novel vaccines is the formulation and delivery of the antigen. Liposomes composed of a dimethyldioctadecylammonium (DDA) backbone and the adjuvant trehalose-6-6-dibehenate (TDB, termed “cationic adjuvant formulation (CAF01)”, promote immunogenicity and protective efficacy of vaccines, most notably against infection with Mycobacterium tuberculosis . Specifically, the multicomponent antige...
Forest Policy / BiosecurityNARA Subscribed
7Massive fires in Indonesian peatlands in the 1990s and in eastern Russian peatlands in 2002 and last year have highlighted the need to manage forests overlying peat deposits, as well as converted peat forests and open peatlands. Peat or peaty soils, contain 65% or more of partially decayed vegetation, can burn freely or underground. They cover some 10 percent of worldwide forests and contain 25 percent of all terrestrial carb...
Silviculture and Forest EcologyNARA Subscribed
2Over the past several decades, federal incentive programs have encouraged the restoration of bottomland forests throughout the West Gulf Coastal Plain (WGCP) and the Lower Mississippi Alluvial Valley (LMAV). Programs such as the Conservation Reserve (CRP) and Wetlands Reserve (WRP) Programs have been marginally successful (Stanturf et al. 2001). Foresters and contractors often follow conventional tree planting procedures that...