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Introduction Toxicologists may use high dose n-acetylcysteine (HD-NAC) for early-treated high-risk acetaminophen ingestions (EHRAI) given concerns over standard NAC (S-NAC) dosing’s efficacy. We utilize the novel, clinically relevant outcome of mean additional 16-hour NAC maintenance infusions (NMI) to evaluate differences in treatment duration for EHRAI patients treated with S-NAC versus HD-NAC. Methods Retrospective multista...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Blue carbon ecosystems, such as mangroves, tidal marshes, and seagrasses, are important for climate mitigation. As carbon sinks, they often exhibit higher per hectare carbon storage capacity and sequestration rates than terrestrial systems. These ecosystems provide additional benefits, including enhancing water quality, sustaining biodiversity, and maintaining coastal resilience to climate change impacts. The widespread loss o...
Voxel-wise insights into early Alzheimer’s disease pathology progression: the association with APOE and memory declineNARA Subscribed
Longitudinal investigation of the Apolipoprotein E (APOE) genotype’s impact on Alzheimer’s disease (AD) biomarker progression, focusing on amyloid beta (Aβ) accumulation and gray matter (GM) atrophy, integrating cognitive decline and baseline levels. Longitudinal florbetapir-PET and T1-weighted MRI data from 100 cognitively normal (CN) and mild cognitive impaired (MCI) participants both with considerable global Aβ accumulation...
Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia predictionNARA Subscribed
DNA methylation age (MA), brain age (BA), and frailty index (FI) are putative aging biomarkers linked to dementia risk. We investigated their relationship and combined potential for prediction of cognitive impairment and future dementia risk using the ADNI database. Of several MA algorithms, DunedinPACE and GrimAge2, associated with memory, were combined in a composite MA alongside BA and a data-driven FI in predictive analyse...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
Ocean practices, intended as a wide spectrum of methodologies supporting ocean-related research, operations, and applications, are constantly developed and improved to enable informed decision-making. Practices start from the idea of an individual or a group and often evolve towards what can be called good or best practices. This bottom-up approach may in principle result in different paths for the evolution of each practice,...
Epidote group minerals, including allanite, clinozoisite and epidote are common in a range of metamorphic, igneous and hydrothermal systems, and are stable across a wide range of pressure – temperature ( P–T ) conditions. These minerals can incorporate substantial amounts of rare earth elements (REEs) during their crystallisation, making them potential candidates for Lu–Hf geochronology to provide age constraints on various ge...
Testing in-situ apatite Lu–Hf dating in polymetamorphic mafic rocks: a case study from Palaeoproterozoic southern AustraliaNARA Subscribed
In mafic systems where primary mineral assemblages have witnessed moderate- to high-temperature hydrous overprinting and deformation, little is known about the retentivity of the Lu–Hf isotopic system in apatite. This study presents apatite laser-ablation Lu–Hf and U–Pb geochronology, zircon geochronology, and detailed petrological information from polymetamorphic mafic intrusions located in the central-western Gawler Craton i...
Mitogenomic evidence of population differentiation of thorny skate, Amblyraja radiata , in the North AtlanticNARA Subscribed
Management of thorny skate ( Amblyraja radiata ) in the Northwest Atlantic has posed a conservation dilemma for several decades due to the species' lack of response to strong conservation efforts in the US Gulf of Maine and the Canadian Scotian Shelf, confusion over the relationship between two reproductive size morphs of differing life histories that are sympatric in the Northwest Atlantic, and conflicting data on regional po...