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Quantification and visualization of 3D facial aging in individuals of European ancestryNARA Subscribed
Facial features undergo continuous transformations across the lifespan. This study quantified and visualized the effects of aging on facial morphology in individuals of European ancestry. Three-dimensional facial photographs of 4,038 individuals (1,455 males and 2,583 females), aged 5 to 85 years and of European descent, were analyzed. Morphological changes in the face were modeled using kernel linear regression, with a focus...
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
The International Union for Conservation of Nature (IUCN) Green Status of Species (GSS), introduced in 2021, is a global standard of measurement used to assess the level to which a species has recovered (i.e., is viable and providing its ecological function across its entire range). It is also used to evaluate how a species has responded to past conservation actions and the expected conservation gains and recovery potential it...
Approximately 30% of sebaceous skin lesions (or sebaceous neoplasia) demonstrate DNA mismatch repair (MMR)-deficiency. MMR-deficiency can be caused by Lynch syndrome, resulting from germline pathogenic variants in the DNA MMR genes MLH1 , MSH2 , MSH6 and PMS2 , but other causes include somatic MLH1 gene promoter hypermethylation, constitutional MLH1 gene promoter hypermethylation ( MLH1 epimutation), or biallelic somatic MMR g...
To assess the viability of locations for wave energy farms and design effective coastal protection measures, knowledge of local wave regimes is required. The work described herein aims to develop a low-cost, self-powering wave-measuring device that comprises a floating buoy with a central moonpool. The relative motion of the water level in the moonpool to the buoy will pressurise and depressurise the air above the water column...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
The Cost of Living with Inherited Ataxia in IrelandNARA Subscribed
Inherited ataxias are a heterogenous group of neurodegenerative disorders characterised by progressive impairment of balance and coordination, typically leading to permanent and progressive disability. Diagnosis and management of these disorders incurs a range of direct and indirect financial costs. The aim of this study was to collect individual ataxia-related healthcare resources in a large cohort of individuals with differe...
A hydrogeological conceptual model of the source, circulation pathways and temporal variation of a low-enthalpy thermal spring in a fractured limestone setting is derived from a multidisciplinary approach. St. Gorman’s Well is a thermal spring in east-central Ireland with a complex and variable temperature profile (maximum of 21.8 °C). Geophysical data from a three-dimensional(3D)audio-magnetotelluric(AMT) survey are combined...
Azole‐resistant Aspergillus fumigatus is highly prevalent in the environment of Vietnam, with marked variability by land use typeNARA Subscribed
Summary Azole‐resistant environmental Aspergillus fumigatus presents a threat to public health but the extent of this threat in Southeast Asia is poorly described. We conducted environmental surveillance in the Mekong Delta region of Vietnam, collecting air and ground samples across key land‐use types, and determined antifungal susceptibilities of Aspergillus section Fumigati (ASF) isolates and azole concentrations in soils. O...
Be Well Communities™: mobilizing communities to promote wellness and stop cancer before it startsNARA Subscribed
Purpose Increasingly, cancer centers are delivering population-based approaches to narrow the gap between known cancer prevention strategies and their effective implementation. Leveraging successful healthy community initiatives, MD Anderson developed Be Well Communities™, a model that implements evidence-based actions to directly impact people’s lives. Methods In partnership with local organizations, MD Anderson’s Be Well Com...
Climate and food web effects on the spring clear‐water phase in two north‐temperate eutrophic lakesNARA Subscribed
Although climate change has shifted the phenological timing of plankton in lakes, few studies have explicitly addressed the relative contributions of climate change and other factors, including planktivory and nutrient availability. The spring clear‐water phase is a period of marked reduction in algal biomass and increased water transparency observed in many lakes. Here, we quantified the phenological patterns in the start dat...
Background Posttraumatic stress disorder is a prevalent mental health condition with substantial impact on daily functioning that lacks sufficient treatment options. Here we evaluate six phase 2 trials in a pooled analysis to determine the study design for phase 3 trials of MDMA-assisted psychotherapy for PTSD. Methods Six randomized, double-blind, controlled clinical trials at five study sites were conducted from April 2004 t...
Trade‐offs for data‐limited fisheries when using harvest strategies based on catch‐only modelsNARA Subscribed
Many of the world's fisheries are unassessed, with little information about population status or risk of overfishing. Unassessed fisheries are particularly predominant in developing countries and in small‐scale fisheries, where they are important for food security. Several catch‐only methods based on time series of fishery catch and commonly available life‐history traits have been developed to estimate stock status (defined as...