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NARA Subscribed1
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Springer Nature1
Journal
Psychopharmacology1
Publication Year
20211
Mark Walzer results 1 · Newest (Page 1/1, per page 25)
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A randomized phase 1 single-dose polysomnography study of ASP8062, a GABAB receptor positive allosteric modulatorNARA Subscribed
Psychopharmacology · 2021 · Vol. 238 · Issue 3 · Springer
Mark Walzer; Ruishan Wu; Maha Ahmad; Jon Freeman; Gary Zammit; Gerard J. Marek
Rationale Previous research suggests that sleep polysomnography and EEG endpoints can be used to assess GABAergic activity; however, the impact of GABA B receptor positive allosteric modulators on sleep endpoints remains unclear. Objectives This phase 1 study compared a single dose of ASP8062 (35 mg or 70 mg), a GABA B receptor positive allosteric modulator, with placebo and paroxetine (40 mg). Methods Healthy adult volunteers...
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