Background Desmin-related cardiomyopathy (DRC) is a proteotoxic disorder driven by mutations in DES and related genes such as CRYAB R120G (R120G), leading to progressive cardiac dysfunction. While late-stage transcriptomic changes in cardiomyopathy and aging are well studied, early molecular events during postnatal maturation and disease onset remain poorly defined. Methods and results Through RNA sequencing of mouse ventricul...

Communication via aggregation pheromones is responsible for the behavioural and ecological characteristics of many species of weevils (Coleoptera). In insects, pheromones are detected by specialized odorant receptors (ORs), called pheromone receptors (PRs), which are usually highly expressed in olfactory sensory neurons localized in the antennae. Yet, PRs in Coleoptera remain understudied, which limits our understanding of the...