The island of Java, Indonesia, is known to have high seismic risk due to its dense population, high seismic hazard and the abundance of seismically vulnerable buildings. However, there is a limited understanding of the spatial distribution of building types and its implications for seismic risk in the island. This gap in understanding primarily stems from the absence of a robust exposure model that covers multiple building use...

The branching green macroalga Cladophora glomerata and its epiphytic microbiome dominate summer biomass in the Eel River, a Northern California river under Mediterranean (summer drought, winter rain) seasonality. Green Cladophora streamers proliferate in early summer, then change to yellow and then red‐brown as epiphyte loads increase. We characterised successional changes in epiphytic bacteria on Cladophora , examining both c...

Improved prediction of drug-induced structural cardiotoxicity is required to reduce attrition driven by cardiac safety concerns in drug discovery. Omics measurements are well suited to this need, offering the potential to discover molecular signatures associated with toxicological endpoints. In addition, untargeted metabolomics can simultaneously measure xenobiotic fate within the test system. We present an extensive metabolom...

Grouping/read-across is widely used for predicting the toxicity of data-poor target substance(s) using data-rich source substance(s). While the chemical industry and the regulators recognise its benefits, registration dossiers are often rejected due to weak analogue/category justifications based largely on the structural similarity of source and target substances. Here we demonstrate how multi-omics measurements can improve co...

Indonesia is located in one of the most seismically active regions in the world and often experiences damaging earthquakes. In the past the housing sector has sustained higher earthquake related damage and losses than other sectors. This is often attributed to the fact that the most common houses in Indonesia are non-engineered, built with poor quality workmanship, poor quality materials and without resilient seismic design fe...

While grouping/read-across is widely used to fill data gaps, chemical registration dossiers are often rejected due to weak category justifications based on structural similarity only. Metabolomics provides a route to robust chemical categories via evidence of shared molecular effects across source and target substances. To gain international acceptance, this approach must demonstrate high reliability, and best-practice guidanc...

Amongst omics technologies, metabolomics should have particular value in regulatory toxicology as the measurement of the molecular phenotype is the closest to traditional apical endpoints, whilst offering mechanistic insights into the biological perturbations. Despite this, the application of untargeted metabolomics for point-of-departure (POD) derivation via benchmark concentration (BMC) modelling is still a relatively unexpl...