Objective This study investigated how cumulative environmental exposures influence offspring behaviour and inflammation-related molecular signatures in the brain and peripheral immune system. Methods A novel "triple-hit" mouse model was developed using C57Bl/6JAusB mice (N = 70), combining preconceptual social stress, antenatal high-fat diet, and a postnatal immune challenge (poly(I:C), 10 mg/kg). At 12 weeks, offspring underw...

Zusammenfassung Das Projekt NIKE-MED zielt darauf ab, die Effizienz und Effektivität der Einsatzkräfte bei der Bewältigung von Notfällen insbesondere bei Großschadensereignissen zu erhöhen, um die Sicherheit der betroffenen Personen zu gewährleisten. Komplexe Einsätze unter Tage sind mit einem Massenanfall von Opfern mit sehr spezifischen Verletzungsmustern, die man aus bewaffneten Konflikten kennt (Vergiftungen, Verbrennungen...

Since the 1980s, Ramularia leaf spot (RLS) is an emerging barley disease worldwide. The control of RLS is increasingly aggravated by a recent decline in fungicide efficacy and a lack of RLS-resistant cultivars. Furthermore, climate change increases drought periods in Europe, enhances variable weather conditions, and thus will have an impact on severity of plant diseases. Hence, identification of RLS-resistant cultivars and und...

During two field campaigns on Lake Issyk‐Kul in March and August 2001, 179 high‐resolution conductivity‐temperature‐depth profiles were measured, along with profiles of dissolved oxygen and light transmission. On the basis of this extensive data set, we investigated the large‐scale vertical advective processes responsible for deepwater renewal in Lake Issyk‐Kul. At some locations sampled in March, variable peak structures in t...

Simultaneous profiles of the transient tracers sulfur hexafluoride (SF 6 ), 3 H‐ 3 He, and the chlorofluorocarbons CFC‐11 and CFC‐12 were measured in Lake Issyk‐Kul, a large, deep lake in Kyrgyzstan. Apparent water ages derived from these measurements suggest rapid mixing, with a deepwater renewal rate >10% yr −1 at 650 m depth. SF 6 and 3H‐3He ages agree reasonably well, whereas CFC ages are significantly greater. The discrep...