Climate change is expected to create a range of impacts on biodiversity, land use, and economic activities, but those sector impacts are rarely analysed together. Here, we assess how climate change and socioeconomic narratives will affect land use and biodiversity in the state of Bavaria, Germany. We apply a multi-sectoral modelling approach with two climate projections (RCP 2.6 and 8.5) downscaled from three different climate...

Purpose In the context of climate change, extreme ambient temperatures pose a major threat to human health. This study aims to provide detailed insights into how extreme temperatures and potential confounders affect respiratory morbidity. Methods We employed a 14-year time series analysis (2006–2019) in southern Germany, applying penalized distributed lag non-linear models to estimate exposure–response relationships between ex...

Leaf phenology, a critical determinant of plant fitness and ecosystem function, is undergoing rapid shifts due to global climate change, yet its complex genetic and environmental drivers remain incompletely understood. Understanding the genetic basis of phenological adaptation is crucial for forecasting forest responses to a changing climate. Here, we integrate multi‐year satellite‐derived phenology from 46 Fagus sylvatica (Eu...

Three collections of clam shrimp from the Lower Devonian (upper lower Emsian) Klerf Formation of Willwerath and Waxweiler in the western Eifel Mountains are herein studied. Four discernible morphotypes are present in the Willwerath assemblage. These morphotypes correspond to the previously described species from this locality: Pseudestheria diensti (Gross), Pseudestheria subcircularis Raymond, and Palaeolimnadiopsis ? eifelens...

Skin cancer patients increasingly search the internet to acquire disease-related information. However, information on the internet may be misleading. Recently, SKINFO has been launched, a website exclusively created for German-speaking skin cancer patients providing information as well as additional resources of verified quality. Here, we describe the results of the first usability test of SKINFO using a mixed-methods approach...

Irritable bowel syndrome (IBS) is a gut-brain disorder of multifactorial origin. Evidence of disturbed serotonergic function in IBS accumulated for the 5-HT 3 receptor family. 5-HT 3 Rs are encoded by HTR3 genes and control GI function, and peristalsis and secretion, in particular. Moreover, 5-HT 3 R antagonists are beneficial in the treatment of diarrhea predominant IBS (IBS-D). We previously reported on functionally relevant...

Despite successful recanalization of large-vessel occlusions in acute ischemic stroke, individual patients profit to a varying degree. Dynamic susceptibility-weighted perfusion and dynamic T1-weighted contrast-enhanced blood-brain barrier permeability imaging may help to determine secondary stroke injury and predict clinical outcome. We prospectively performed perfusion and permeability imaging in 38 patients within 24 h after...

HMG-CoA-Reductase inhibitors (HMGRIs) are currently the most widely used group of drugs in patients with coronary artery disease (CAD) and are given preemptively to patients with high levels of cholesterol, including those with diabetes mellitus (DM). However, intake of HMGRIs also increases the progression of coronary artery calcification (CAC) and the risk of developing DM. This study aimed to investigate whether HMGRI intak...

SARS-CoV-2 has emerged as a previously unknown zoonotic coronavirus that spread worldwide causing a serious pandemic. While reliable nucleic acid–based diagnostic assays were rapidly available, only a limited number of validated serological assays were available in the early phase of the pandemic. Here, we evaluated a novel flow cytometric approach to assess spike-specific antibody responses.HEK 293T cells expressing SARS-CoV-...