The existence of thresholds for carcinogenic compounds is an important topic in toxicology and regulatory science. Traditionally, genotoxic carcinogens are thought to exhibit no thresholds. However, cellular defense mechanisms like DNA repair and apoptosis can neutralize low levels of genotoxic stress implying different Points of Departure (PoDs) for different cellular endpoints. Moreover, since cellular PoDs are regulated by...

Purpose Unrecognized contraindications pose risks for adverse drug reactions, hospitalizations or death. Clinical decision support systems (CDSS) aim to mitigate medication-related harm, particularly originating from contraindications. However, many CDSS provide limited benefit, as they focus largely on singular risk situations such as drug-drug interactions and often generate alerts of limited clinical relevance. Comprehensiv...

Zusammenfassung Die Studie untersucht die Entwicklung der Grundwasserstände in Deutschland anhand von 5844 Messstellen sowie deren Reaktionsdynamik gegenüber klimatologischen Antrieben im Referenzzeitraum 1991–2020. Zusätzlich wird die Entwicklung seit 2018 im Kontext der außergewöhnlichen Dürreperiode betrachtet, um die Reaktionsfähigkeit und Vulnerabilität der Grundwassersysteme gegenüber extremen klimatischen Bedingungen zu...

The consumption of milk can contribute to the consumers` exposure to aflatoxin as aflatoxin M 1 (AFM 1 ), a hydroxylated metabolite of aflatoxin B 1 (AFB 1 ), is transferred into the milk of AFB 1 exposed dairy cows. As mitigation measures against AFB 1 presence in cattle feed, fungal biocontrol strains are applied on plant materials to reduce toxigenic A. flavus growth. The present study investigates the impact of applying tw...

Digital transformation is the key to turning public authorities into organisations that make decisions based on data-driven insights. Big geodata analysis can enable public authorities to tackle complex sustainability issues in order to achieve long-term goals. However, the efficient management of large amounts of geodata through the implementation of viable and state-of-the-art data infrastructures represents a major challeng...

Synthetic cannabinoids (SCs) are consumed as an alternative to cannabis. Novel compounds are developed by minor modifications in their chemical structure, e.g. insertion of a carboxamide moiety as a linker, which can potentially lead to altered toxicokinetics (TK). Knowledge on the TK data of SCs, especially structural modified substances, is scarce. Hence, interpretation of toxicological results is challenging. Therefore, the...

Many fatal intoxications have been reported in connection with the consumption of newer, highly potent synthetic cannabinoids. Yet, a possible postmortem redistribution (PMR) might complicate reliable interpretation of analytical results. Thus, it is necessary to investigate the PMR-potential of new synthetic cannabinoids. The pig model has already proven to be suitable for this purpose. Hence, the aim of this study was to stu...

Aim Understanding the mechanisms promoting resilience in plant communities is crucial in times of increasing disturbance and global environmental change. Here, we present the first meta‐analysis evaluating the relationship between functional diversity and resilience of plant communities. Specifically, we tested whether the resilience of plant communities is positively correlated with interspecific trait variation (following th...

Climate change effects on tree reproduction are poorly understood, even though the resilience of populations relies on sufficient regeneration to balance increasing rates of mortality. Forest‐forming tree species often mast, i.e. reproduce through synchronised year‐to‐year variation in seed production, which improves pollination and reduces seed predation. Recent observations in European beech show, however, that current clima...

Lymph node metastasis (LNM) occurs in less than 5% of soft tissue sarcoma (STS) patients and indicates an aggressive course of disease. Suspicious lymph nodes (LN) in staging imaging are a frequent topic of discussion in multidisciplinary tumor boards. Predictive markers are needed to facilitate stratification and improve treatment of STS patients. In this study, 56 STS patients with radiologically suspicious and subsequently...