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CyberKnife stereotactic radiosurgery (SRS) treatment of multiple brain metastases (MBM) using fixed cone collimation is well established. This study aims to rigorously evaluate the commissioning of MBM SRS using feasible complex clinical scenarios. Sixteen gross tumour volumes (GTVs) were contoured on the CT of an in-house developed phantom. Six treatment plans, testing different levels of complexity, were generated using the...
This study identifies amide proton transfer (APT) imaging radiomic features that correlate with glioblastoma survival and explore the relationship of combined radiomic data and biomarkers such as age and MGMT methylation status to survival prognosis. In a retrospective study of 66 glioblastoma patients (2022–2023), SlicerBrats was used for automatic tumor segmentation and 504 radiomic features were extracted from APT images. A...
Distribution of coastal blue carbon habitats in Sweden and their exposure to anthropogenic pressureNARA Subscribed
Understanding where blue carbon habitats occur and how they are affected by human activity contributes to effective management of natural carbon sinks. Here, we compiled geographical data for Sweden to map the distribution of coastal vegetated blue carbon (BC) habitats. The mapping effort focused on well-recognised (salt marshes and seagrass meadows) and emergent BC habitats (other rooted submerged macrophytes and forested wet...
The deportment of silver in Kupferschiefer ores at the Spremberg-Graustein-Schleife deposit, GermanyNARA Subscribed
The high-grade stratabound copper ores of the Central European Kupferschiefer are one of the world’s most important sources of silver. Despite its economic significance, the mineralogical partitioning of silver within the Kupferschiefer ores is generally not well understood, other than the fact that silver minerals are not sufficiently abundant to account for the bulk of the silver content. This study provides the first fully...
Advantages of carbon fibre-reinforced polyetheretherketone over titanium implants in spine SBRT: a phantom evaluationNARA Subscribed
This study evaluates the clinical feasibility of spine stereotactic body radiotherapy (SBRT) in the presence of titanium and carbon fibre-reinforced polyetheretherketone (CFR-PEEK) spinal implants using custom 3D-printed phantoms. The investigation focuses on the dosimetric accuracy, imaging challenges, and achievable localisation precision. Customised 3D-printed phantoms incorporating titanium and CFR-PEEK implants were compu...
Guidance on selecting and evaluating AI auto-segmentation systems in clinical radiotherapy: insights from a six-vendor analysisNARA Subscribed
Artificial Intelligence (AI) based auto-segmentation has demonstrated numerous benefits to clinical radiotherapy workflows. However, the rapidly changing regulatory, research, and market environment presents challenges around selecting and evaluating the most suitable solution. To support the clinical adoption of AI auto-segmentation systems, Selection Criteria recommendations were developed to enable a holistic evaluation of...
Evaluating the prognostic value of radiomics and clinical features in metastatic prostate cancer using [68Ga]Ga-PSMA-11 PET/CTNARA Subscribed
Prostate cancer is a significant global health issue due to its high incidence and poor outcomes in metastatic disease. This study aims to develop models predicting overall survival for patients with metastatic biochemically recurrent prostate cancer, potentially helping to identify high-risk patients and enabling more tailored treatment options. A multi-centre cohort of 180 such patients underwent [ 68 Ga]Ga-PSMA-11 PET/CT sc...
Mechanistic in silico explorations of the immunogenic and synergistic effects of radiotherapy and immunotherapy: a critical reviewNARA Subscribed
Immunotherapy is a rapidly evolving field, with many models attempting to describe its impact on the immune system, especially when paired with radiotherapy. Tumor response to this combination involves a complex spatiotemporal dynamic which makes either clinical or pre-clinical in vivo investigation across the resulting extensive solution space extremely difficult. In this review, several in silico models of the interaction be...
Assessing focal spot alignment in clinical linear accelerators: a comprehensive evaluation with triplet phantomsNARA Subscribed
A fundamental parameter to evaluate the beam delivery precision and stability on a clinical linear accelerator (linac) is the focal spot position (FSP) measured relative to the collimator axis of the radiation head. The aims of this work were to evaluate comprehensive data on FSP acquired on linacs in clinical use and to establish the ability of alternative phantoms to detect effects on patient plan delivery related to FSP. FS...
Dosimetric comparison of proton therapy and CyberKnife in stereotactic body radiation therapy for liver cancersNARA Subscribed
Stereotactic body radiation therapy (SBRT) has been increasingly used for the ablation of liver tumours. CyberKnife and proton beam therapy (PBT) are two advanced treatment technologies suitable to deliver SBRT with high dose conformity and steep dose gradients. However, there is very limited data comparing the dosimetric characteristics of CyberKnife to PBT for liver SBRT. PBT and CyberKnife plans were retrospectively generat...
Construction and validation of an infant chest phantom for paediatric computed tomographyNARA Subscribed
Paediatric imaging protocols should be carefully optimised to maintain the desired image quality while minimising the delivered patient dose. A paediatric chest phantom was designed, constructed and evaluated to optimise chest CT examinations for infants. The phantom was designed to enable dosimetry and image quality measurements within the anthropomorphic structure. It was constructed using tissue equivalent materials to mimi...
Development of a 3D printed phantom for commissioning and quality assurance of multiple brain targets stereotactic radiosurgeryNARA Subscribed
Single plan techniques for multiple brain targets (MBT) stereotactic radiosurgery (SRS) are now routine. Patient specific quality assurance (QA) for MBT poses challenges due to the limited capabilities of existing QA tools which necessitates several plan redeliveries. This study sought to develop an SRS QA phantom that enables flexible MBT patient specific QA in a single delivery, along with complex SRS commissioning. PLA marb...
Validation of small field dosimetry is crucial for stereotactic radiosurgery (SRS) and stereotactic body radiotherapy (SBRT). Accurate and considered measurement of linear accelerator dose must be compared to precise and accurate calculation by the treatment planning system (TPS). Monte Carlo calculated distributions contain statistical noise, reducing the reliance that should be given to single voxel doses. The average dose t...
Dosimetric evaluation of an intraoperative radiotherapy system: a measurement-based and Monte-Carlo modelling investigationNARA Subscribed
Intraoperative radiotherapy (IORT) is a specialised subset of radiotherapy, where a high radiation dose is delivered to a surgically exposed tumour bed in order to eradicate any remaining cancer cells. The aim of this study was to examine the dose characteristics of the Zeiss Intrabeam IORT device which provides near-isotropic emission of up to 50 kV X-rays. The EGSnrc Monte Carlo (MC) code system was used to simulate the devi...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...