Martin Neumann results 54
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Purpose Unrecognized contraindications pose risks for adverse drug reactions, hospitalizations or death. Clinical decision support systems (CDSS) aim to mitigate medication-related harm, particularly originating from contraindications. However, many CDSS provide limited benefit, as they focus largely on singular risk situations such as drug-drug interactions and often generate alerts of limited clinical relevance. Comprehensiv...
Temperate Forest Floors: Ecosystem Hubs in Transition?NARA Subscribed
The forest floor (FF) plays a key role in carbon, nutrient, and water cycling. It is the biologically most active compartment of forest soils, highly responsive to environmental conditions. Yet, its response to current changes in environmental conditions and forest management is understudied. Temperate forests are among the best studied ecosystems globally, providing the necessary ecological and biogeochemical background infor...
On the origin of the late-flowering ppd-H1 allele in barleyNARA Subscribed
To breed for climate resilient crops, an understanding of the genetic and environmental factors influencing adaptation is critical. Barley provides a model species to study adaptation to climate change. Here we present a detailed analysis of genetic variation at a major photoperiod response locus and relate this to the domestication history and dispersal of barley. The PPD-H1 locus (a PSEUDO-RESPONSE REGULATOR 7 ) promotes flo...
Aquatic ecosystems in mountainous regions are crucial for fulfilling natural and anthropogenic water demands around the world. This study integrates Escherichia coli ( E. coli ) enumeration, microbial source tracking (MST), and environmental DNA (eDNA) analysis to identify sources of fecal contamination in oligotrophic mountain waters. Conducted in an area with intense tourism and traditional reindeer herding, this research ad...
Within a citizen science project, 112 freshwater habitats in Austria were sampled to get bacterial cultures belonging to the genus Aquirufa using a strategy for targeted isolation. We focused on these bacteria because they are widespread and represent typical freshwater bacteria and, furthermore, the typic red pigmentation facilitates preselection. Among the 113 obtained Aquirufa strains were HETE-83D T , KTFRIE-69F T , OSTEIC...
This study investigates the dynamics of sediment and phosphorus transport in small streams affected by recurrent flood waves. The experiments were carried out in two streams with contrasting conditions: one in an agricultural headwater section, which serves as a sediment source, and the other in a mid-water section influenced by fish ponds. High-frequency data on suspended sediment and phosphorus concentrations were collected...
Congenital adrenal hyperplasia (CAH) is characterized by impaired adrenal cortisol production. Hydrocortisone (synthetic cortisol) is the drug-of-choice for cortisol replacement therapy, aiming to mimic physiological cortisol circadian rhythm. The hypothalamic-pituitary-adrenal (HPA) axis controls cortisol production through the pituitary adrenocorticotropic hormone (ACTH) and feedback mechanisms. The aim of this study was to...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
TGFβ signalling pathway impacts brain metastases profiles in locally advanced colorectal cancerNARA Subscribed
Rationale Colorectal Cancer (CRC) represents the third most common type of cancer in Germany and the second most common cancer-related cause of death worldwide. Distant metastases are still the main limit for patient survival. While liver metastases as well as peritoneal carcinomatosis can often either be resected or treated with systemic therapy, little options remain for brain metastases. Additionally, a number of studies ha...
Strains LEOWEIH-7C T and LEPPI-3A were isolated from the Leopoldskroner Weiher, a lake located in the city of Salzburg, Austria. 16S rRNA gene similarities and phylogenetic reconstructions with 16S rRNA gene sequences as well as based on genome sequences revealed that the new strains belong to the A. antheringensis branch of the genus Aquirufa . Calculated whole-genome average nucleotide identity (gANI) and digital DNA–DNA hyb...
In previous studies, we demonstrated the involvement of H 4 R in inflammatory bowel disease (IBD) and IBD-associated colon cancer in mice and could ascribe H 4 R-mediated histamine function to colon epithelial cells. The transferability of obtained data to humans is however lacking. Functional expression of H 4 R on colon epithelial cells is a prerequisite to pursue the hypothesis of involvement of H 4 R in carcinogenesis. Thu...
The Toxicology Investigators Consortium 2022 Annual ReportNARA Subscribed