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Springer Nature1
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Archives of Toxicology1
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20201
Martin Stockmann results 1 · Newest (Page 1/1, per page 25)
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A novel variant of the 13C-methacetin liver function breath test that eliminates the confounding effect of individual differences in systemic CO2 kineticsNARA Subscribed
Archives of Toxicology · 2020 · Vol. 94 · Issue 2 · Springer
Hermann-Georg Holzhütter; Tilo Wuensch; Robert Gajowski; Nikolaus Berndt; Sascha Bulik; David Meierhofer; Martin Stockmann
The principle of dynamic liver function breath tests is founded on the administration of a 13 C-labeled drug and subsequent monitoring of 13 CO 2 in the breath, quantified as time series delta over natural baseline 13 CO 2 (DOB) liberated from the drug during hepatic CYP-dependent detoxification. One confounding factor limiting the diagnostic value of such tests is that only a fraction of the liberated 13 CO 2 is immediately e...
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