Ultrasound (US)-mediated drug delivery is a promising strategy for localised, minimally invasive molecular transport, typically relying on microbubble-assisted sonoporation. However, clinical translation is limited by the short half-life, cost, and cytotoxicity of exogenous microbubbles. In this proof-of-concept study, we present a microbubble-free, mechanically driven sonoporation approach for intracellular delivery of hydrop...