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Real-time beat-to-beat pulse wave velocity estimation: a quality-driven approach using laser Doppler vibrometryNARA Subscribed
Arterial stiffness, a key cardiovascular risk marker, is typically assessed via carotid-femoral pulse wave velocity (cf-PWV), the gold-standard method. In this study, we introduce CAPE (Continuous Automatic PWV Estimation), an innovative framework for near real-time cf-PWV estimation based on beat-to-beat analysis of laser-Doppler vibrometry (LDV) signals. CAPE integrates automatic fiducial point detection, systematic signal q...
Purpose Bloodstream infections (BSIs) pose a significant health threat, requiring effective diagnostic processes to ensure appropriate treatment. Monitoring the quality of blood cultures (BCs) process (the cornerstone of BSIs etiological diagnosis) is critical. This study aimed to describe an automated tool, BD DREAM™ (Digital Remote Extraction Analysis & Monitoring), designed for monitoring key performance indicators (KPIs) i...
The italian national genomic strategy: current status, challenges, and future perspectives in clinical practice and public healthNARA Subscribed
This article presents the outcomes of a national initiative aimed at developing a technical document to support the future Italian National Genomic Strategy, carried out from 2021 to 2024 through the collaboration of 14 research institutions. The project was designed to align with major European genomic initiatives, particularly the “1 + Million Genomes” (1 + MG) Declaration and its supporting programs, including Beyond 1 Mill...
miR-92a-3p and miR-320a are Upregulated in Plasma Neuron-Derived Extracellular Vesicles of Patients with Frontotemporal DementiaNARA Subscribed
Despite the efforts to identify fluid biomarkers to improve diagnosis of Frontotemporal dementia (FTD), only a few candidates have been described in recent years. In a previous study, we identified three circulating miRNAs (miR-92a-3p, miR-320a and miR-320b) differentially expressed in FTD patients with respect to healthy controls and/or Alzheimer’s disease (AD) patients. Now, we investigated whether those changes could be due...
Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severityNARA Subscribed
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the pr...
Marine animal forests are benthic communities dominated by sessile suspension feeders (such as sponges, corals, and bivalves) able to generate three-dimensional (3D) frameworks with high structural complexity. The biodiversity and functioning of marine animal forests are strictly related to their 3D complexity. The present paper aims at providing new perspectives in underwater optical surveys. Starting from the current gaps in...
The main purpose of this paper is to describe a software platform dedicated to sea surveillance, capable of detecting and identifying illegal maritime traffic. This platform results from the cascade pipeline of several image processing algorithms that input Radar or Optical imagery captured by satellite-borne sensors and try to identify vessel targets in the scene and provide quantitative descriptors about their shape and moti...
Biophysical aspects of biomineralizationNARA Subscribed