To address the hyper-inflammation associated with cystic fibrosis (CF) lung disease, we evaluated the efficacy of inhalable Nano into Micro (NiM) formulations carrying a repurposed anti-inflammatory agent, i.e. Iloprost (ILO), a prostacyclin analogue. Nasal epithelial brushings were obtained from 15 individuals with CF bearing at least one F508del mutation. The isolated cells were expanded using the conditional reprogramming c...

The main aim of this work was to synthesize new chitosan amphiphilic derivatives able to self-assembly encapsulating substances acting at different target sites implicated in Parkinson disease (PD). For this purpose, O -carboxymethyl-chitosan ( O -CMCS) was grafted with dopamine (DA) exploiting a carbodiimide mediated coupling reaction using different polymer/DA weight ratios. The structural characterization of the resulting O...

Cystic fibrosis (CF) is a disease characterized by the production of viscous mucoid secretions in multiple organs, particularly the airways. The pathological increase of proteins, mucin and biological polymers determines their arrangement into a three-dimensional polymeric network, affecting the whole mucus and impairing the muco-ciliary clearance which promotes inflammation and bacterial infection. Thus, to improve the effica...

Summary Given the widespread presence of Burkholderia cenocepacia in the rhizosphere it is important to determine whether rhizosphere strains are pathogenic for cystic fibrosis patients or not. Eighteen B. cenocepacia strains of rhizosphere and clinical origin were typed by multi‐locus sequence typing (MLST) analysis and compared for their ability to invade pulmonary epithelial cells and their virulence in a mouse model of air...