The study consisted of two experiments. First, a PK experiment was set up with a single oral dose at 20 mg/kg body weight, and second, a withdrawal time determination study, where the fish were fed once a day for 5 consecutive days at the same dosage. The DOX concentration in medicated feed, fish muscle, plasma, liver, and kidney was analysed by LC–MS/MS. Phoenix 8.1 and WT 1.4 software were used in the calculation for PK para...

Florfenicol (FF) is one of the common antimicrobials used to control bacterial disease in shrimp aquaculture. This study aimed to determine the pharmacokinetics (PK) parameters of FF in white leg shrimp plasma, hepatopancreas and muscle as well as its residue depletion in shrimp muscle and the impact on shrimp hepatopancreas histology during and after FF medication. In the PK experiment, shrimp were fed once at 10 mg FF/kg bod...

The mycotoxins alternariol (AOH) and alternariol monomethyl ether (AME), produced by Alternaria spp . , are common contaminants of food and feed and are a potential threat to animal and human health. To date, the most prominent data gaps for their comprehensive risk assessment concern information on their in vivo absorption, distribution, metabolism and excretion (ADME) and toxicokinetic behavior. The aim of this study was to...

A high-performance liquid chromatography method coupled to tandem mass spectrometry was validated in order to study the pharmacokinetics of cefotaxime in shrimp hepatopancreases and plasma, as well as its withdrawal time related to a maximum residue limit (MRL) in shrimp muscle. Pharmacokinetics parameters were investigated through oral medication at a single dose of 25 mg/kg shrimp body weight and subsequent hepatopancreas an...