Toxicology is undergoing a paradigm shift, driven by the ethical imperative to reduce animal testing, the pursuit of sustainability, and regulatory transitions toward new approach methodologies (NAMs). This study systematically maps the integration of ethics and sustainability into NAMs-related toxicological research, using a mixed-methods design that combines bibliometric analysis with a review of scientific and policy litera...

Reperfusion following myocardial infarction salvages the ischemic heart but paradoxically exacerbates injury. Yet, efficient treatment for cardiac ischemia/reperfusion injury is still missing in clinics. ATP release through Pannexin1 (PANX1) channels facilitates recruitment of leukocytes to the injured myocardium. Thus, PANX1 channel inhibition might confer cardioprotection. Currently available PANX1 channel blockers lack spec...