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Springer Nature1
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Pflügers Archiv - European Journal of Physiology1
Publication Year
20231
Matthias Preller results 1 · Newest (Page 1/1, per page 25)
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Pharmacological inhibitors of the cystic fibrosis transmembrane conductance regulator exert off-target effects on epithelial cation channelsNARA Subscribed
Pflügers Archiv - European Journal of Physiology · 2023 · Vol. 475 · Issue 2 · Springer
JinHeng Lin; Sean M. Gettings; Khaoula Talbi; Rainer Schreiber; Michael J. Taggart; Matthias Preller; Karl Kunzelmann; Mike Althaus; Michael A. Gray
The cystic fibrosis transmembrane conductance regulator (CFTR) anion channel and the epithelial Na + channel (ENaC) play essential roles in transepithelial ion and fluid transport in numerous epithelial tissues. Inhibitors of both channels have been important tools for defining their physiological role in vitro. However, two commonly used CFTR inhibitors, CFTR inh -172 and GlyH-101, also inhibit non-CFTR anion channels, indica...
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